Search: onr:"swepub:oai:DiVA.org:liu-202318" >
Ixazomib, Lenalidom...
Ixazomib, Lenalidomide, and Dexamethasone (IRD) Treatment with Cytogenetic Risk-Based Maintenance in Transplant-Eligible Myeloma: A Phase 2 Multicenter Study by the Nordic Myeloma Study Group
-
- Partanen, Anu (author)
- Kuopio Univ Hosp, Finland
-
- Waage, Anders (author)
- St Olavs Hosp, Norway
-
- Peceliunas, Valdas (author)
- Vilnius Univ Hosp, Lithuania
-
show more...
-
- Schjesvold, Fredrik (author)
- Oslo Univ Hosp, Norway; Univ Oslo, Norway
-
- Anttila, Pekka (author)
- Univ Helsinki, Finland
-
- Saeily, Marjaana (author)
- Oulu Univ Hosp Hematol, Finland
-
- Uttervall, Katarina (author)
- Karolinska Institutet,Karolinska Univ Hosp, Sweden; Karolinska Inst, Sweden
-
- Putkonen, Mervi (author)
- Turku Univ Hosp, Finland
-
- Carlson, Kristina (author)
- Uppsala Univ Hosp, Sweden
-
- Haukas, Einar (author)
- Stavanger Univ Hosp, Norway
-
- Sankelo, Marja (author)
- Tampere Univ Hosp Hematol, Finland
-
- Szatkowski, Damian (author)
- Foerde Cent Hosp, Norway
-
- Hansson, Markus (author)
- Skane Univ Hosp, Sweden
-
- Marttila, Anu (author)
- Kymenlaakso Cent Hosp, Finland
-
- Svensson, Ronald (author)
- Region Östergötland, Hematologiska kliniken US
-
- Axelsson, Per (author)
- Helsingborg Hosp, Sweden
-
- Lauri, Birgitta (author)
- Sunderby Hosp, Sweden
-
- Mikkola, Maija (author)
- Karolinska Institutet,Paijat Hame Cent Hosp, Finland
-
- Karlsson, Conny (author)
- Halland Hosp, Sweden
-
- Abelsson, Johanna (author)
- Uddevalla Cent Hosp, Sweden
-
- Ahlstrand, Erik (author)
- Orebro Univ Hosp, Sweden
-
- Sikioe, Anu (author)
- Cent Finland Cent Hosp, Finland
-
- Klimkowska, Monika (author)
- Karolinska Univ Hosp, Sweden
-
- Matuzeviciene, Reda (author)
- Vilnius Univ Hosp, Lithuania; Vilnius Univ, Lithuania
-
- Fenstad, Mona Hoysaeter (author)
- St Olavs Hosp, Norway
-
- Ilveskero, Sorella (author)
- Univ Helsinki, Finland
-
- Pelliniemi, Tarja-Terttu (author)
- Fimlab Labs Ltd, Finland
-
- Nahi, Hareth (author)
- Karolinska Institutet,Karolinska Univ Hosp Huddinge, Sweden
-
- Silvennoinen, Raija (author)
- Univ Helsinki, Finland
-
show less...
-
(creator_code:org_t)
- MDPI, 2024
- 2024
- English.
-
In: Cancers. - : MDPI. - 2072-6694. ; 16:5
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.3...
-
http://kipublication...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- Scarce data exist on double maintenance in transplant-eligible high-risk (HR) newly diagnosed multiple myeloma (NDMM) patients. This prospective phase 2 study enrolled 120 transplant-eligible NDMM patients. The treatment consisted of four cycles of ixazomib-lenalidomide-dexamethasone (IRD) induction plus autologous stem cell transplantation followed by IRD consolidation and cytogenetic risk-based maintenance therapy with lenalidomide + ixazomib (IR) for HR patients and lenalidomide (R) alone for NHR patients. The main endpoint of the study was undetectable minimal residual disease (MRD) with sensitivity of <10-5 by flow cytometry at any time, and other endpoints were progression-free survival (PFS) and overall survival (OS). We present the preplanned analysis after the last patient has been two years on maintenance. At any time during protocol treatment, 28% (34/120) had MRD < 10-5 at least once. At two years on maintenance, 66% of the patients in the HR group and 76% in the NHR group were progression-free (p = 0.395) and 36% (43/120) were CR or better, of which 42% (18/43) had undetectable flow MRD <10-5. Altogether 95% of the patients with sustained MRD <10-5, 82% of the patients who turned MRD-positive, and 61% of those with positive MRD had no disease progression at two years on maintenance (p < 0.001). To conclude, prolonged maintenance with all-oral ixazomib plus lenalidomide might improve PFS in HR patients.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- multiple myeloma; ixazomib; autologous stem cell transplantation; measurable residual disease; progression-free survival; maintenance
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
-
Cancers
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
-
Partanen, Anu
-
Waage, Anders
-
Peceliunas, Vald ...
-
Schjesvold, Fred ...
-
Anttila, Pekka
-
Saeily, Marjaana
-
show more...
-
Uttervall, Katar ...
-
Putkonen, Mervi
-
Carlson, Kristin ...
-
Haukas, Einar
-
Sankelo, Marja
-
Szatkowski, Dami ...
-
Hansson, Markus
-
Marttila, Anu
-
Svensson, Ronald
-
Axelsson, Per
-
Lauri, Birgitta
-
Mikkola, Maija
-
Karlsson, Conny
-
Abelsson, Johann ...
-
Ahlstrand, Erik
-
Sikioe, Anu
-
Klimkowska, Moni ...
-
Matuzeviciene, R ...
-
Fenstad, Mona Ho ...
-
Ilveskero, Sorel ...
-
Pelliniemi, Tarj ...
-
Nahi, Hareth
-
Silvennoinen, Ra ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cancer and Oncol ...
- Articles in the publication
-
Cancers
- By the university
-
Linköping University
-
Karolinska Institutet