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Elevation of S2-bou...
Elevation of S2-bound a1-acid glycoprotein is associated with chronic hepatitis C virus infection and hepatocellular carcinoma
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- Oltmanns, Carlos (author)
- Hannover Med Sch MHH, Germany; Ctr Individualised Infect Med CiiM, Germany; Hannover Med Sch, Germany; TWINCORE, Germany; Hannover Med Sch, Germany
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- Bremer, Birgit (author)
- Hannover Med Sch MHH, Germany; Hannover Med Sch, Germany
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- Kusche, Laura (author)
- Hannover Med Sch MHH, Germany
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- Stal, Per (author)
- Karolinska Institutet
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- Zenlander, Robin (author)
- Karolinska Institutet
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- Tauwaldt, Jan (author)
- Hannover Med Sch MHH, Germany; Ctr Individualised Infect Med CiiM, Germany; Hannover Med Sch, Germany; TWINCORE, Germany
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- Rydén, Ingvar (author)
- Linköpings universitet,Avdelningen för klinisk kemi och farmakologi,Medicinska fakulteten
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- Påhlsson, Peter (author)
- Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten
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- Cornberg, Markus (author)
- Hannover Med Sch MHH, Germany; Ctr Individualised Infect Med CiiM, Germany; Hannover Med Sch, Germany; TWINCORE, Germany; German Ctr Infect Res DZIF, Germany
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- Wedemeyer, Heiner (author)
- Hannover Med Sch MHH, Germany; Hannover Med Sch, Germany; German Ctr Infect Res DZIF, Germany
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(creator_code:org_t)
- 2024
- 2024
- English.
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In: Journal of Viral Hepatitis. - : WILEY. - 1352-0504 .- 1365-2893.
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- There is an urgent need for new high-quality markers for the early detection of hepatocellular carcinoma (HCC). angstrom strom et al. suggested that S2-bound alpha 1-acid glycoprotein (AGP) might be a promising marker. Consequently, we evaluated the predictive advantage of S2-bound AGP in the early detection of HCC. In a retrospective case-control study of patients chronically infected with hepatitis C virus (HCV) and treated with direct-acting antiviral agents (n = 93), we measured S2-bound AGP using the HepaCheC (R) ELISA kit (Glycobond AB, Linkoping, SE) at the start of treatment, end of treatment and follow-up (maximum: 78 months). Patients were retrospectively propensity score matched (1:2). Thirty-one patients chronically infected with HCV developed HCC after a sustained virological response, while 62 did not. In addition, samples of patients with chronic hepatitis B virus infection, metabolic dysfunction-associated steatotic liver disease and HCC of different etiologies were analysed. S2-bound AGP elevation in HCC patients was confirmed. However, we did not observe a predictive advantage of S2-bound AGP for the early detection of HCC during treatment and follow-up. Interestingly, S2-bound AGP levels correlated with aspartate aminotransferase (rho = .56, p = 9.5x10-15) and liver elastography (rho = .67, p = 2.2x10-16). Of note, S2-bound AGP decreased in patients chronically infected with HCV after treatment-induced HCV clearance. Fucosylated S2-bound AGP levels were elevated in patients with chronic HCV and HCC. The potential role of S2-bound AGP as a novel tumour marker requires further investigation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Keyword
- AST; biomarker; cancer; elastography; HBV; HCC; HCV; MASLD; S2-bound AGP; surveillance
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Oltmanns, Carlos
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Bremer, Birgit
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Kusche, Laura
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Stal, Per
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Zenlander, Robin
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Tauwaldt, Jan
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show more...
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Rydén, Ingvar
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Påhlsson, Peter
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Cornberg, Markus
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Wedemeyer, Heine ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Gastroenterology ...
- Articles in the publication
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Journal of Viral ...
- By the university
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Linköping University
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Karolinska Institutet