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Rapid change of neu...
Rapid change of neuropeptide Y levels and gene-expression in the brain of ovariectomized mice after administration of 17 beta-estradiol
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- Hilke, Susanne (author)
- Linköpings universitet,Klinisk kemi,Hälsouniversitetet
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- Holm, Lovisa, 1962- (author)
- Linköpings universitet,Klinisk kemi,Hälsouniversitetet
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- Aman, Katarina (author)
- Karolinska Institute
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- Hokfelt, Tomas (author)
- Karolinska Institutet
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- Theodorsson, Elvar (author)
- Östergötlands Läns Landsting,Linköpings universitet,Klinisk kemi,Hälsouniversitetet
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(creator_code:org_t)
- Elsevier BV, 2009
- 2009
- English.
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In: NEUROPEPTIDES. - : Elsevier BV. - 0143-4179 .- 1532-2785. ; 43:4, s. 327-332
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Subject headings
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- Estrogen alters excitability and changes synaptic morphology in the rat hippocampal formation. We have compared, by means of radioimmunoassay and in situ hybridization, the effects of short-term treatment with 17 beta-estradiol on neuropeptide Y (NPY) in the brain of ovariectomized mice. A highly significant reduction in concentrations of NPY-like immunoreactivity (LI) was observed in the hippocampal formation, some cortical areas and the caudate nucleus 1 h after administration of 17 beta-estradiol as compared to the control group. In contrast, NPY transcript levels increased in the hippocampal formation (dentate gyrus) and the caudate nucleus, possibly representing a compensatory increase of NPY synthesis following increased estradiol-induced NPY release. These data suggest that 17 beta-estradiol, via membrane-related mechanisms, increases NPY release and synthesis in forebrain areas involved in cognition, mood and motor functions.
Keyword
- Estrogen
- In situ hybridization
- Limbic system
- Neuropeptide
- Radioimmunoassay
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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