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Microcirculatory ch...
Microcirculatory changes in type 2 diabetes assessed with velocity resolved quantitative laser Doppler flowmetry
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- Fredriksson, Ingemar, 1980- (author)
- Linköpings universitet,Biomedicinsk instrumentteknik,Tekniska högskolan
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- Larsson, Marcus (author)
- Linköpings universitet,Institutionen för medicinsk teknik,Biomedicinsk instrumentteknik
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- Nyström, Fredrik (author)
- Linköpings universitet,Institutionen för medicin och hälsa,Kardiologi
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- Länne, Toste (author)
- Linköpings universitet,Institutionen för medicin och hälsa,Kardiologi
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- Östgren, Carl Johan (author)
- Östergötlands Läns Landsting,Linköpings universitet,Allmänmedicin,Hälsouniversitetet,Primärvården i västra länsdelen
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- Strömberg, Tomas (author)
- Linköpings universitet,Biomedicinsk instrumentteknik,Tekniska högskolan
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(creator_code:org_t)
- English.
- Related links:
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http://urn.kb.se/res...
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Abstract
Subject headings
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- The response to local heating (44oC for 20 min) was evaluated in 28 type 2 diabetes patients (DM) and 29 non-diabetes controls (ND). Microcirculatory perfusion was assessed using conventional and quantitative Laser Doppler flowmetry (cLDF and qLDF), respectively. The qLDF estimates perfusion in a physiological relevant unit (g RBC / 100 g tissue × mm/s) in a fixed output volume, separated into three velocity regions, v < 1 mm/s, 1 - 10 mm/s, and v > 10 mm/s. Perfusion in cLDF is given in arbitrary units with unknown velocity distribution and measurement volume. A significantly lower response in DM than in ND was found after heat provocation both for the initial peak and the plateau response, while no significant differences were found at baseline. The qLDF showed increased perfusion for the velocity regions 1-10 mm/s and above 10 mm/s, while no significant increase was found for v < 1 mm/s. In conclusion, we found a lowered LDF response to local heating in DM. The new qLDF method showed that the increased blood flow occurs in vessels with a velocity above 1 mm/s. Baseline qLDF-data indicated that a redistribution of flow to higher velocity regions was associated with longer DM duration and for DM a negative correlation between perfusion and BMI.
Subject headings
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Medicinsk laboratorie- och mätteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Medical Laboratory and Measurements Technologies (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomedicinsk laboratorievetenskap/teknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomedical Laboratory Science/Technology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- Medical engineering
- Medicinsk teknik
- Medical technology
- Medicinsk teknik
- Diabetology
- Diabetologi
Publication and Content Type
- vet (subject category)
- ovr (subject category)
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