Search: onr:"swepub:oai:DiVA.org:liu-205164" >
Identification and ...
Identification and validation of a blood- based diagnostic lipidomic signature of pediatric inflammatory bowel disease
-
- Salihovic, Samira, Associate Senior Lecturer, 1985- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Orebro Univ, Sweden
-
- Nystrom, Niklas (author)
- Uppsala Univ, Sweden,Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden
-
- Mathisen, Charlotte Bache-Wiig (author)
- Oslo Univ Hosp, Norway; Univ Oslo, Norway,Department of Gastroenterology, Oslo University Hospital, Oslo, Norway and Faculty of Medicine, University of Oslo, Oslo, Norway
-
show more...
-
- Kruse, Robert, 1972- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Clinical Research Laboratory, Faculty of Medicine and Health, Örebro University, Örebro, Sweden,Orebro Univ, Sweden
-
- Olbjorn, Christine (author)
- Akershus Univ Hosp, Norway,Department of Pediatrics and Adolescent Medicine, Akershus University Hospital, Lørenskog, Norway
-
- Andersen, Svend (author)
- Vestfold Hosp Trust, Norway,Department of Pediatrics, Vestfold Hospital Trust, Tønsberg, Norway
-
- Noble, Alexandra J. (author)
- Univ Oxford, England,Translational Gastroenterology Unit, Nuffield Department of Experimental Medicine, University of Oxford, Oxford, United Kingdom; Biomedical Research Center, University of Oxford, Oxford, United Kingdom
-
- Dorn-Rasmussen, Maria (author)
- Copenhagen Univ Hosp Amager & Hvidovre, Denmark; Copenhagen Univ Hosp Amager & Hvidovre, Denmark,Department of Paediatric and Adolescence Medicine, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark; Copenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark
-
- Bazov, Igor, 1973- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Orebro Univ, Sweden
-
- Perminow, Gori (author)
- Oslo Univ Hosp, Norway,Department of Pediatric Medicine, Oslo University Hospital, Oslo, Norway
-
- Opheim, Randi (author)
- Oslo Univ Hosp, Norway; Univ Oslo, Norway,Department of Gastroenterology, Oslo University Hospital, Oslo, Norway and Faculty of Medicine, University of Oslo, Oslo, Norway
-
- Detlie, Trond Espen (author)
- Akershus Univ Hosp, Norway; Univ Oslo, Norway,Department of Gastroenterology, Akershus University Hospital, Lørenskog, Norway and Faculty of Medicine, University of Oslo, Oslo, Norway
-
- Huppertz-Hauss, Gert (author)
- Telemark Hosp Trust, Norway,Department of Gastroenterology, Telemark Hospital Trust, Skien, Norway
-
- Hedin, Charlotte R. H. (author)
- Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden,Karolinska Institutet, Department of Medicine Solna, Stockholm, Sweden; Karolinska University Hospital, Gastroenterology unit, Department of Gastroenterology, Dermatovenereology and Rheumatology, Stockholm, Sweden
-
- Carlson, Marie (author)
- Uppsala Univ, Sweden,Department of Medical Sciences, Uppsala University, Uppsala, Sweden
-
- Ohman, Lena (author)
- Univ Gothenburg, Sweden,Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
-
- Magnusson, Maria K. (author)
- Univ Gothenburg, Sweden,Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
-
- Keita, Åsa (author)
- Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden
-
- Söderholm, Johan D (author)
- Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Kirurgiska kliniken US,Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden
-
- D'Amato, Mauro (author)
- Basque Fdn Sci, Spain; CIC bioGUNE BRTA, Spain; LUM Univ, Italy,IKERBASQUE, Basque Foundation for Science, Bilbao, Spain; Gastrointestinal Genetics Lab, CIC bioGUNE - BRTA, Derio, Spain; Department of Medicine & Surgery, LUM University, Casamassima, Italy
-
- Oresic, Matej, 1967- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland,Orebro Univ, Sweden; Univ Turku, Finland; Abo Akad Univ, Finland
-
- Wewer, Vibeke (author)
- Copenhagen Univ Hosp Amager & Hvidovre, Denmark; Copenhagen Univ Hosp Amager & Hvidovre, Denmark,Department of Paediatric and Adolescence Medicine, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark; Copenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark
-
- Satsangi, Jack (author)
- Univ Oxford, England; Univ Oxford, England,Translational Gastroenterology Unit, Nuffield Department of Experimental Medicine, University of Oxford, Oxford, United Kingdom; Biomedical Research Center, University of Oxford, Oxford, United Kingdom
-
- Lindqvist, Carl Mårten, 1979- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Orebro Univ, Sweden
-
- Burisch, Johan (author)
- Copenhagen Univ Hosp Amager & Hvidovre, Denmark; Copenhagen Univ Hosp Amager & Hvidovre, Denmark,Copenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark; Gastrounit, medical division, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark
-
- Uhlig, Holm H. (author)
- Univ Oxford, England; Univ Oxford, England; Univ Oxford, England,Translational Gastroenterology Unit, Nuffield Department of Experimental Medicine, University of Oxford, Oxford, United Kingdom; Biomedical Research Center, University of Oxford, Oxford, United Kingdom; Department of Paediatrics, University of Oxford, Oxford, UK
-
- Repsilber, Dirk, 1971- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Orebro Univ, Sweden
-
- Hyötyläinen, Tuulia, 1971- (author)
- Örebro universitet,Institutionen för naturvetenskap och teknik,Orebro Univ, Sweden
-
- Hoivik, Marte Lie (author)
- Oslo Univ Hosp, Norway; Univ Oslo, Norway,Department of Gastroenterology, Oslo University Hospital, Oslo, Norway and Faculty of Medicine, University of Oslo, Oslo, Norway
-
- Halfvarson, Jonas, 1970- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden,Orebro Univ, Sweden
-
show less...
-
(creator_code:org_t)
- NATURE PORTFOLIO, 2024
- 2024
- English.
-
In: Nature Communications. - : NATURE PORTFOLIO. - 2041-1723. ; 15:1
- Related links:
-
https://doi.org/10.1...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
show less...
Abstract
Subject headings
Close
- Improved biomarkers are needed for pediatric inflammatory bowel disease. Here we identify a diagnostic lipidomic signature for pediatric inflammatory bowel disease by analyzing blood samples from a discovery cohort of incident treatment-na & iuml;ve pediatric patients and validating findings in an independent inception cohort. The lipidomic signature comprising of only lactosyl ceramide (d18:1/16:0) and phosphatidylcholine (18:0p/22:6) improves the diagnostic prediction compared with high-sensitivity C-reactive protein. Adding high-sensitivity C-reactive protein to the signature does not improve its performance. In patients providing a stool sample, the diagnostic performance of the lipidomic signature and fecal calprotectin, a marker of gastrointestinal inflammation, does not substantially differ. Upon investigation in a third pediatric cohort, the findings of increased lactosyl ceramide (d18:1/16:0) and decreased phosphatidylcholine (18:0p/22:6) absolute concentrations are confirmed. Translation of the lipidomic signature into a scalable diagnostic blood test for pediatric inflammatory bowel disease has the potential to support clinical decision making. Diagnostic blood-based biomarkers of pediatric IBD are limited. Here, the authors demonstrate a diagnostic lipidomic signature, comprising only of two molecular lipids. Translation of this signature into a scalable test has the potential to support clinical decision making.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Salihovic, Samir ...
-
Nystrom, Niklas
-
Mathisen, Charlo ...
-
Kruse, Robert, 1 ...
-
Olbjorn, Christi ...
-
Andersen, Svend
-
show more...
-
Noble, Alexandra ...
-
Dorn-Rasmussen, ...
-
Bazov, Igor, 197 ...
-
Perminow, Gori
-
Opheim, Randi
-
Detlie, Trond Es ...
-
Huppertz-Hauss, ...
-
Hedin, Charlotte ...
-
Carlson, Marie
-
Ohman, Lena
-
Magnusson, Maria ...
-
Keita, Åsa
-
Söderholm, Johan ...
-
D'Amato, Mauro
-
Oresic, Matej, 1 ...
-
Wewer, Vibeke
-
Satsangi, Jack
-
Lindqvist, Carl ...
-
Burisch, Johan
-
Uhlig, Holm H.
-
Repsilber, Dirk, ...
-
Hyötyläinen, Tuu ...
-
Hoivik, Marte Li ...
-
Halfvarson, Jona ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Rheumatology and ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Gastroenterology ...
- Articles in the publication
-
Nature Communica ...
- By the university
-
Linköping University
-
Örebro University