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Evaluation of tubul...
Evaluation of tubulin ß-3 and 5 hydroxy-methyl cytosine as diagnostic and prognostic markers in malignant melanoma
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- Lundmark, Katarzyna (author)
- Linköpings universitet,Institutionen för biomedicinska och kliniska vetenskaper,Medicinska fakulteten,Region Östergötland, Klinisk patologi
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- Orfanidis, Kyriakos (author)
- Linköpings universitet,Institutionen för biomedicinska och kliniska vetenskaper,Medicinska fakulteten,Region Östergötland, Hudkliniken i Östergötland
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- Vainikka, Linda (author)
- Linköpings universitet,Institutionen för biomedicinska och kliniska vetenskaper,Medicinska fakulteten
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- Synnerstad, Ingrid (author)
- Linköpings universitet,Institutionen för biomedicinska och kliniska vetenskaper,Medicinska fakulteten,Region Östergötland, Hudkliniken i Östergötland
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- Wäster, Petra (author)
- Linköpings universitet,Avdelningen för klinisk kemi och farmakologi,Medicinska fakulteten
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- Öllinger, Karin (author)
- Linköpings universitet,Avdelningen för cell- och neurobiologi,Medicinska fakulteten
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(creator_code:org_t)
- ELSEVIER SCIENCE INC, 2024
- 2024
- English.
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In: Annals of Diagnostic Pathology. - : ELSEVIER SCIENCE INC. - 1092-9134 .- 1532-8198. ; 72L
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Tubulin beta-3 staining pattern and staining intensity of 5-hydroxymethyl cytosine (5-hmC) are potential diagnostic and prognostic markers in melanocytic lesions that need further evaluation. Melanocytic nevi and primary cutaneous melanomas were immunohistochemically stained for tubulin-beta-3 and 5-hmC. Immunoreactivity and staining patterns were correlated with Breslow-thickness, clinical and pathological characteristics, and progression-free survival. Melanocytes showed positive tubulin beta-3 staining. However, in most nevi, tubulin beta-3 staining appeared as a gradient with intense cytoplasmic staining in cells of the superficial part of the lesion that faded to weak staining in the deep dermal part, while no gradient was found in deep penetrating nevi and melanomas. In 53 % of the melanomas, areas with loss of tubulin beta-3 staining were found. 5-hmC staining intensity was significantly higher in melanocytic nevi compared to melanomas. Breslow thickness in combination with low 5-hmC score and loss of tubulin-beta-3 staining was predictive for poor prognosis. As single markers, tubulin-beta-3 and 5-hmC can be useful to distinguish between melanocytic nevi and melanoma, but staining variability limits the use of 5-hmC. In melanomas measuring >1.5 mm, combination of low 5-hmC score and loss of tubulin-beta-3 staining may have prognostic value.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Melanoma; Nevus; Diagnostic marker; beta-Tubulin; 5-hmC
Publication and Content Type
- ref (subject category)
- art (subject category)
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