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Magnesium release f...
Magnesium release from mesoporous carriers on endosseus implants does not influence bone maturation at 6 weeks in rabbit bone.
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- Galli, Silvia (author)
- Malmö högskola,Odontologiska fakulteten (OD),Malmö universitet,Malmö university
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- Andersson, Martin, 1974 (author)
- Department of Chemistry and Chemical Engineering, Applied Chemistry, Chalmers University of Technology, 412 96, Gothenburg, Sweden,Chalmers tekniska högskola,Chalmers University of Technology
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- Jinno, Yohei (author)
- Malmö högskola,Odontologiska fakulteten (OD),Malmö universitet,Malmö university
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- Karlsson, Johan (author)
- Department of Chemistry and Chemical Engineering, Applied Chemistry, Chalmers University of Technology, 412 96, Gothenburg, Sweden,Chalmers tekniska högskola,Chalmers University of Technology
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- He, Wenxiao, 1985 (author)
- Department of Chemistry and Chemical Engineering, Applied Chemistry, Chalmers University of Technology, 412 96, Gothenburg, Sweden,Chalmers tekniska högskola,Chalmers University of Technology
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- Xue, Ying (author)
- Department of Clinical Dentistry, Center for Clinical Dental Research, University of Bergen, Norway,Universitetet i Bergen,University of Bergen
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- Mustafa, Kamal (author)
- Department of Clinical Dentistry, Center for Clinical Dental Research, University of Bergen, Norway,Universitetet i Bergen,University of Bergen
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- Wennerberg, Ann (author)
- Malmö högskola,Odontologiska fakulteten (OD),Malmö universitet,Malmö university
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- Jimbo, Ryo (author)
- Malmö högskola,Odontologiska fakulteten (OD),Malmö universitet,Malmö university
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(creator_code:org_t)
- 2016-07-13
- 2017
- English.
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In: Journal of Biomedical Materials Research. Part B - Applied biomaterials. - : Wiley. - 1552-4973 .- 1552-4981. ; 105:7, s. 2118-2125
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Abstract
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- OBJECTIVES: The release of magnesium ions (Mg2+ ) from titanium surfaces has been shown to boost the initial biological response of peri-implant bone and to increase the biomechanical strength of osseointegration. The objective of the present paper was to investigate if the initial improvement in osseointegration would influence the bone remodeling also during the maturation stage of bone healing.METHODS: Titanium implants were coated with mesoporous titania layers and either loaded with Mg2+ (test group) or left untreated (control group). The implants were inserted in the tibiae of 10 New Zealand White rabbits. Osseointegration was assessed after 6 weeks by means of biomechanical testing (RTQ), non-decalcified histology and histomorphometry (BIC%, BA%, NBA%). The expression of genes involved in the bone formation and remodeling was quantified using qPCR.RESULTS: Mg2+ releasing mesoporous titania coatings showed, on average, higher removal torques and histomorphometrical outcomes (RTQ: 17.2 Ncm vs. 15 Ncm; BIC: 38.8% vs. 32.1%; BA%: 71.6% vs. 64%; NBA% 62.5% vs. 54% for the tests vs the controls); however, the differences were not statistically significant. Three osteogenic markers, osteocalcin (OC), collagen 1 alpha 1 (COL1A1), and alkalin phosphatase (ALPL), were respectively 2-fold, 1.53-fold, and 1.13-fold up-regulated in the control group compared to the test. The expression of COL1A1 was particularly high in both groups, while the biomarkers for remodeling and inflammation showed a low expression in both groups.SIGNIFICANCE: The results suggested that the initial enhancement in osseointegration induced by magnesium release from mesoporous titania coatings has no detrimental effects during bone maturation. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 2118-2125, 2017.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Medicinsk material- och protesteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Medical Materials (hsv//eng)
Keyword
- bone remodeling
- magnesium
- mesoporous titania
- osseointegration
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Galli, Silvia
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Andersson, Marti ...
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Jinno, Yohei
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Karlsson, Johan
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He, Wenxiao, 198 ...
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Xue, Ying
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show more...
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Mustafa, Kamal
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Wennerberg, Ann
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Jimbo, Ryo
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Dentistry
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- ENGINEERING AND TECHNOLOGY
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ENGINEERING AND ...
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and Medical Engineer ...
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and Medical Material ...
- Articles in the publication
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Journal of Biome ...
- By the university
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Linköping University
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Malmö University
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Chalmers University of Technology