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COPD-Like Phenotype...
COPD-Like Phenotypes in TBC-Treated Mice Can be Effectively Alleviated via Estrogen Supplement
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- Zhang, Wenjuan (author)
- Jianghan Univ, Peoples R China
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- Wang, Yuxin (author)
- Jianghan Univ, Peoples R China
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- Wang, Ling (author)
- Jianghan Univ, Peoples R China
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- Cao, Mengxi (author)
- Jianghan Univ, Peoples R China
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- Cao, Huiming (author)
- Jianghan Univ, Peoples R China
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- Song, Maoyong (author)
- Jianghan Univ, Peoples R China; Chinese Acad Sci, Peoples R China
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- Qian, Yun (author)
- Florida Int Univ, FL 33174 USA
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- Wang, Thanh (author)
- Linköpings universitet,Kemi,Tekniska fakulteten,Tema Miljöförändring,Filosofiska fakulteten
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- Liang, Yong (author)
- Jianghan Univ, Peoples R China
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- Jiang, Guibin (author)
- Chinese Acad Sci, Peoples R China
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(creator_code:org_t)
- 2024
- 2024
- English.
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In: Environmental Science and Technology. - : AMER CHEMICAL SOC. - 0013-936X .- 1520-5851.
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Tris(2,3-dibromopropyl) isocyanurate (TBC), recognized as an endocrine disruptor, can cause inflammatory injury to the lung tissue of mice. To investigate the specific respiratory effects of TBC, male C57BL/6J mice were administered a daily dose of 20 mg/kg of TBC over 14 days. Postexposure, these mice developed chronic obstructive pulmonary disease (COPD)-like symptoms characterized by inflammatory lung damage and functional impairment. In light of the antiestrogenic properties of TBC, we administrated estradiol (E2) to investigate its potential protective role against TBC-induced damage and found that the coexposure of E2 notably mitigated the COPD-like phenotypes. Immunohistochemical analysis revealed that TBC exposure reduced estrogen receptor alpha (ER alpha) expression and increased nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappa B) expression, while E2 treatment rebalanced the expression levels of ER alpha and NF-kappa B to their normative states. Our findings indicate that TBC, as an antiestrogenic agent, may contribute to the pathogenesis of COPD through an ER alpha-mediated inflammatory pathway, but that E2 treatment could reverse the impairment, providing a potentially promising remedial treatment. Given the lung status as a primary target of air pollution, the presence of antiestrogenic compounds like TBC in atmospheric particulates presents a significant concern, with the potential to exacerbate respiratory conditions such as COPD and pneumonia.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Andra medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Other Basic Medicine (hsv//eng)
Keyword
- tris(2
- 3-dibromopropyl) isocyanurate; chronic obstructivepulmonary disease; estradiol; pulmonary dysfunction; estrogen receptor alpha
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Zhang, Wenjuan
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Wang, Yuxin
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Wang, Ling
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Cao, Mengxi
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Cao, Huiming
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Song, Maoyong
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show more...
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Qian, Yun
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Wang, Thanh
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Liang, Yong
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Jiang, Guibin
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Other Basic Medi ...
- Articles in the publication
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Environmental Sc ...
- By the university
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Linköping University