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Transmissibility of...
Transmissibility of systemic amyloidosis by a prion-like mechanism
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- Lundmark, Katarzyna (author)
- Linköpings universitet,Molekylär och immunologisk patologi,Hälsouniversitetet
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- Westermark, Gunilla T. (author)
- Linköpings universitet,Cellbiologi,Hälsouniversitetet
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- Nyström, Sofia (author)
- Linköpings universitet,Cellbiologi,Hälsouniversitetet
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- Murphy, Charles L. (author)
- Human Immunology and Cancer Program, University of Tennessee Graduate School of Medicine, Knoxville, TN 37996, USA
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- Solomon, Alan (author)
- Human Immunology and Cancer Program, University of Tennessee Graduate School of Medicine, Knoxville, TN 37996, USA
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- Westermark, Per (author)
- Department of Genetics and Pathology, Uppsala University, 751 85 Uppsala, Sweden
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(creator_code:org_t)
- 2002-05-14
- 2002
- English.
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In: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 99:10, s. 6979-6984
- Related links:
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http://www.pnas.org/...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- The generation of amyloid fibrils from an amyloidogenic polypeptide occurs by a nucleation-dependent process initiated in vitro by seeding the protein solution with preformed fibrils. This phenomenon is evidenced in vivo by the fact that amyloid protein A (AA) amyloidosis in mice is markedly accelerated when the animals are given, in addition to an inflammatory stimulus, an i.v. injection of protein extracted from AA amyloid-laden mouse tissue. Heretofore, the chemical nature of this “amyloid enhancing factor” (AEF) has not been definitively identified. Here we report that the active principle of AEF extracted from the spleen of mice with silver nitrate-induced AA amyloidosis was identified unequivocally as the AA fibril itself. Further, we demonstrated that this material was extremely potent, being active in doses <1 ng, and that it retained its biologic activity over a considerable length of time. Notably, the AEF was also effective when administered orally. Our studies have provided evidence that AA and perhaps other forms of amyloidosis are transmissible diseases, akin to the prion-associated disorders.
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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