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Mutation and accumu...
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Stenmark Askmalm, Marie
(author)
Mutation and accumulation of p53 related to results of adjuvant therapy of postmenopausal breast cancer patients
- Article/chapterEnglish2004
Publisher, publication year, extent ...
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2009-07-08
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Informa UK Limited,2004
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:liu-22385
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-22385URI
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https://doi.org/10.1080/02841860410029474DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:1959554URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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p53 protein accumulation and gene mutation have been implicated in resistance to cytotoxic treatment. This study was performed to further assess the predictive value of p53 in breast cancer. Postmenopausal patients were randomized to adjuvant chemotherapy with cyclophosphamide, metothrexate, or 5-fluorouracil (CMF) vs. Postoperative radiotherapy. The patients were also randomized to adjuvant tamoxifen vs. No endocrine treatment. Immunohistochemistry (IHC) and single-strand conformation polymorphism (SSCP), followed by direct sequencing, was performed. The p53 altered group, regarded as positive for p53 gene mutation and/or p53 protein accumulation, tended to benefit more from CMF than from radiotherapy as compared with others regarding distant recurrences. In the group lacking p53 alteration there was a significantly decreased local recurrence rate in the radiotherapy group as compared with the CMF group (RR = 0.24, 95% CI = 0.083-0.62), whereas no benefit from radiotherapy was found for patients snowing p53 alterations. Tamoxifen significantly decreased the rate of distant recurrence for estrogen receptor-positive patients with no apparent difference in relation to p53 alteration. It is suggested that p53 alteration indicates benefit from CMF compared with radiotherapy regarding distant recurrence-free survival and the best local control with radiotherapy is achieved in the absence of p53 alteration. Finally, altered p53 status is probably not a marker of resistance to tamoxifen.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Carstensen, John,1953-Linköpings universitet,Institutionen för hälsa och samhälle(Swepub:liu)johca98
(author)
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Nordenskjöld, Bo,1940-Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Onkologi,Onkologiska kliniken US(Swepub:liu)bono64
(author)
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Olsson, Birgit,1946-Linköpings universitet,Hälsouniversitetet,Onkologi(Swepub:liu)birol93
(author)
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Rutqvist, Lars Erik
(author)
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Skoog, LambertKarolinska Institutet
(author)
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Stål, Olle,1952-Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Onkologi,Onkologiska kliniken US(Swepub:liu)ollst87
(author)
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Linköpings universitetInstitutionen för hälsa och samhälle
(creator_code:org_t)
Related titles
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In:Acta Oncologica: Informa UK Limited43:3, s. 235-2440284-186X1651-226X
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