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- Nissinen, RDept of Mol Med National Publ Health, Helsingfors, Finland (author)
Cytokine and chemokine receptor profile of peripheral blood mononuclear cells during treatment with infliximab in patients with active rheumatoid arthritis
- Article/chapterEnglish2004
Publisher, publication year, extent ...
- 2004-03-17
- BMJ,2004
- printrdacarrier
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- LIBRIS-ID:oai:DiVA.org:liu-22460
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-22460URI
- https://doi.org/10.1136/ard.2003.008599DOI
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- Language:English
- Summary in:English
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- Objectives: To analyse immunological changes during treatment with a monoclonal anti-tumour necrosis factor α (TNFα) antibody, infliximab, in patients with rheumatoid arthritis (RA). Methods: 25 patients with RA and 5 patients with other arthritides were studied during the first 6 weeks of treatment with infliximab. At the start of treatment and after 2 and 6 weeks, spontaneous expression of CCR3 and CCR5 on peripheral blood T cells and monocytes was studied by flow cytometry. The secretion and mRNA expression of interferon γ (IFNγ), interleukin (IL)4, IL5, and TNFα from phytohaemagglutinin (PHA) stimulated peripheral blood mononuclear cells was measured with an ELISA and RT-PCR. Plasma levels of C reactive protein, serum amyloid protein A, rheumatoid factor, and antibodies to filaggrin and citrullinated cyclic peptide were measured with an ELISA. Results: The number of CD4 T cells and CD14 monocytes expressing CCR3 (p = 0.013, p = 0.009, respectively) and CD8 T cells expressing CCR5 (p = 0.040) as well as PHA stimulated secretion of IL4 and IFNγ (p<0.05) increased during treatment in patients with RA. 15 (60%) patients with RA achieved clinical response (at least ACR20) during the first 2 weeks. The number of T cells expressing CCR3 and CCR5 was higher before treatment in non-responders than in responders (p<0.05). The number of T cells increased in responders. Conclusion: Increase in secretion of Th1 and Th2 cytokines together with induced expression of chemokine receptors on T cells and monocytes suggest restoration of peripheral cell mediated immunity and blockade of the accumulation of inflammatory cells in joints as response to treatment.
Subject headings and genre
- MEDICINE
- MEDICIN
Added entries (persons, corporate bodies, meetings, titles ...)
- Leirisalo-Repo, MDept of Medicine, Div of Rheumatol Central Hospital, Helsingfors, Finland (author)
- Peltomaa, RDept of MEdicine, Div of Rheumatol Central Hospital, Helsingfors, Finland (author)
- Palosuo, TDept of Health and Functional Capacity National Public Health Inst, Helsingfors, Finland (author)
- Vaarala, Outi,1962-Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Pediatrik,Barn- och ungdomskliniken i Linköping(Swepub:liu)outva41 (author)
- Dept of Mol Med National Publ Health, Helsingfors, FinlandDept of Medicine, Div of Rheumatol Central Hospital, Helsingfors, Finland (creator_code:org_t)
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- In:Annals of the Rheumatic Diseases: BMJ63:6, s. 681-6870003-49671468-2060
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