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EEG abnormalities w...
EEG abnormalities with and without relation to severe hypoglycaemia in adolescents with type 1 diabetes
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- Hyllienmark, Lars (author)
- Karolinska Institutet
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- Maltez, J (author)
- Avd f Klin neurofysiologi Karolinska sjukhuset, Stockholm
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- Dandenell, AnnaKarin (author)
- Barnkliniken US
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- Ludvigsson, Johnny, 1943- (author)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Pediatrik,Barn- och ungdomskliniken i Linköping
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- Brismar, Tom (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2005-03-01
- 2005
- English.
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In: Diabetologia. - : Springer Science and Business Media LLC. - 0012-186X .- 1432-0428. ; 48:3, s. 412-419
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Abstract
Subject headings
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- Aims/hypothesis: The aim of the present study was to identify whether adolescents with type 1 diabetes receiving modern multiple insulin injection therapy (MIT) have abnormal EEGs, and to elucidate possible correlations with a history of severe hypoglycaemia, poor metabolic control and nerve conduction defects. Methods: We investigated 35 patients (age 14-19 years) with disease duration 7.6±4.6 years, and 45 healthy control subjects. EEG spectral components were obtained from 15-min recordings in resting, awake subjects. Nerve conduction was measured bilaterally in motor and sensory fibres in the median, peroneal and sural nerves. Results: The EEGs of patients showed an increase in slow activity (delta and theta) and a reduction in alpha peak frequency, both of which were most pronounced in the frontal regions (p<0.001). They also showed a decrease in fast activity, which was most pronounced bilaterally in the posterior temporal regions (alpha p<0.001, beta p<0.01, gamma p<0.001). A history of severe hypoglycaemia was correlated with a global increase in theta activity (p<0.01-0.05). Poor metabolic control, measured as acute and long-term HbA1c levels, was correlated with an increase in delta activity and a decrease in alpha peak frequency. The decrease in fast activity in the temporal regions was a separate type of abnormality because it had a different distribution, and was not correlated with the increase in delta/theta power, poor metabolic control or with hypoglycaemia. Conclusions/interpretation: Recurrent severe hypoglycaemia and poor metabolic control are risk factors for EEG abnormalities in adolescents with type 1 diabetes receiving MIT treatment. In addition, we found pronounced abnormalities in the temporal regions that were not related to these risk factors. © Springer-Verlag 2005.
Keyword
- Adolescents
- EEG
- glycosylated haemoglobin
- hypoglycaemia
- metabolic control
- type 1 diabetes
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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