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Association of breast cancer progression with a vitamin D receptor gene polymorphism
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- Lundin, Anna-Carin (author)
- Linköpings universitet,Cellbiologi,Hälsouniversitetet
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- Söderkvist, Peter, 1953- (author)
- Linköpings universitet,Cellbiologi,Hälsouniversitetet
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- Eriksson, Birgitta (author)
- Linköpings universitet,Cellbiologi,Hälsouniversitetet
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- (creator_code:org_t)
- 1999
- 1999
- English.
- In: Cancer Research. - 0008-5472 .- 1538-7445. ; 59:10, s. 2332-2334
- Journal article (peer-reviewed)
Abstract
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- The vitamin D3 receptor gene (VDR) contains a TaqI RFLP that is associated with increased VDR mRNA stability, increased serum levels of 1α,25-dihydroxyvitamin D3 (1,25-D3), and decreased risk for prostate cancer. Determination of the TaqI genotype, in a group of young women with breast cancer (n = 111; age, <37 years) and a control population (n = 130), revealed no overall association to risk for breast cancer. However, patients without TaqI site (TT genotype) showed a significantly increased risk for lymph node metastasis (relative risk, 1.8, 95% confidence interval, 1.3- 2.6). Furthermore, a tendency toward an increased survival was found among estrogen receptor-positive, tamoxifen-treated patients who were homozygous for the TaqI site (P = 0.075). We conclude that polymorphism in the VDR gene may influence tumor progression and tamoxifen treatment response in early- onset breast carcinomas.
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