Search: onr:"swepub:oai:DiVA.org:liu-24935" >
Catechol-O-Methyltr...
Catechol-O-Methyltransferase (COMT) gene polymorphism and breast cancer risk in young women
-
- Bergman-Jungeström, Malin, 1967- (author)
- Linköpings universitet,Onkologi,Hälsouniversitetet
-
- Wingren, Sten, 1950- (author)
- Linköpings universitet,Onkologi,Hälsouniversitetet
-
(creator_code:org_t)
- 2001-09-11
- 2001
- English.
-
In: British Journal of Cancer. - : Springer Science and Business Media LLC. - 0007-0920 .- 1532-1827. ; 85:6, s. 859-862
- Related links:
-
https://www.nature.c...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Oestrogen exposure has long been considered to be a main risk factor of breast cancer. More recently, interest has also focused on the possible carcinogenic influence from oestrogen metabolites, such as catechol oestrogens. O-methylation, catalysed by Catechol-O-Methyltransferase (COMT), is one pathway by which the potentially carcinogenic catechol oestrogens can be inactivated. The gene coding for COMT protein contains a single-nucleotide polymorphism (SNP), resulting in an amino acid shift Val Met, which has been shown to determine high- and low-activity configuration of the enzyme. We hypothesized that the low-activity allele, COMTMet, may be implicated in early onset breast cancer. In the present case–control study, including 126 young breast cancer patients ( 36 years) and 117 healthy female blood donors, we analysed the association between COMTMet genotype and risk of breast cancer. No significant difference in the frequency of low-/high-activity alleles was found between cases and controls, indicating that the polymorphism, as a single factor, may not contribute to breast carcinogenesis in young women.
Keyword
- Catechol-O-Methyltransferase
- COMT
- genetic polymorphism
- breast cancer
- early onset
- catechol oestrogens
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database