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Catechol-O-Methyltransferase (COMT) gene polymorphism and breast cancer risk in young women

Bergman-Jungeström, Malin, 1967- (author)
Linköpings universitet,Onkologi,Hälsouniversitetet
Wingren, Sten, 1950- (author)
Linköpings universitet,Onkologi,Hälsouniversitetet
 (creator_code:org_t)
2001-09-11
2001
English.
In: British Journal of Cancer. - : Springer Science and Business Media LLC. - 0007-0920 .- 1532-1827. ; 85:6, s. 859-862
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Oestrogen exposure has long been considered to be a main risk factor of breast cancer. More recently, interest has also focused on the possible carcinogenic influence from oestrogen metabolites, such as catechol oestrogens. O-methylation, catalysed by Catechol-O-Methyltransferase (COMT), is one pathway by which the potentially carcinogenic catechol oestrogens can be inactivated. The gene coding for COMT protein contains a single-nucleotide polymorphism (SNP), resulting in an amino acid shift Val Met, which has been shown to determine high- and low-activity configuration of the enzyme. We hypothesized that the low-activity allele, COMTMet, may be implicated in early onset breast cancer. In the present case–control study, including 126 young breast cancer patients ( 36 years) and 117 healthy female blood donors, we analysed the association between COMTMet genotype and risk of breast cancer. No significant difference in the frequency of low-/high-activity alleles was found between cases and controls, indicating that the polymorphism, as a single factor, may not contribute to breast carcinogenesis in young women.

Keyword

Catechol-O-Methyltransferase
COMT
genetic polymorphism
breast cancer
early onset
catechol oestrogens
MEDICINE
MEDICIN

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