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Expression of cytos...
Expression of cytosolic and group X secretory phospholipase A2 genes in human colorectal adenocarcinomas
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- Österström, Anna (author)
- Linköpings universitet,Hälsouniversitetet,Cellbiologi
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Dimberg, Jan (author)
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- Fransén, Karin, 1973- (author)
- Linköpings universitet,Hälsouniversitetet,Cellbiologi
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- Söderkvist, Peter, 1953- (author)
- Linköpings universitet,Hälsouniversitetet,Cellbiologi
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(creator_code:org_t)
- 2002
- 2002
- English.
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In: Cancer Letters. - 0304-3835 .- 1872-7980. ; 182:2, s. 175-182
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Gene expression of cytosolic phospholipase A2 (cPLA2) and protein level of secretory PLA2 group X (sPLA2-X) are upregulated in human colorectal cancer and provide cyclooxygenase-2 (COX-2) with arachidonic acid, resulting in increased levels of PGE2. Mutated ras-genes are suggested to be involved in the regulatory pathway of cPLA2 in lung cancer cells. We analysed the gene expression of cPLA2 and sPLA2-X in 42 and 38 primary colorectal tumours, respectively, with and without K-ras mutations. We found an up-regulation of cPLA2 mRNA but the induction in tumour tissues does not correlate with Ras-gene mutations. Moreover, our results cannot consistently reflect an overexpression of sPLA2-X gene in colorectal cancer tissues.
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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