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Immunisation of metastatic cancer patients with MAGE-3 protein combined with adjuvant SBAS-2 : A clinical report
- Marchand, M (author)
- Punt, CJA (author)
- Aamdal, S (author)
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- Escudier, B (author)
- Kruit, WHJ (author)
- Keilholz, U (author)
- van Baren, N (author)
- Humblet, Y (author)
- Mulders, P (author)
- Avril, M-F (author)
- Eggermont, AMM (author)
- Scheibenbogen, C (author)
- Uiters, J (author)
- Wanders, J (author)
- Delire, M (author)
- Boon, T (author)
- Stoter, G (author)
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- (creator_code:org_t)
- 2003
- 2003
- English.
- In: European Journal of Cancer. - 0959-8049 .- 1879-0852. ; 39:1, s. 70-77
- Journal article (peer-reviewed)
Abstract
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- Fifty-seven patients with MAGE-3-positive measurable metastatic cancer, most of them with melanoma, were vaccinated with escalating doses of a recombinant MAGE-3 protein combined with a fixed dose of the immunological adjuvant SBAS-2, which contained MPL and QS21. The immunisation schedule included 4 intramuscular (i.m.) injections at 3-week intervals. Patients whose tumour stabilised or regressed after 4 vaccinations received 2 additional vaccinations at 6-week intervals. The vaccine was generally well tolerated. Among the 33 melanoma patients who were evaluable for tumour response, we observed 2 partial responses, 2 mixed responses and 1 stabilisation. Time to progression in these 5 patients varied from 4 to 29 months. In addition, a partial response lasting 10 months was observed in 1 of the 3 metastatic bladder cancer patients included. None of the tumour responses described above involved visceral metastases. Immunological responses to the vaccine will be reported separately. ⌐ 2002 Elsevier Science Ltd. All rights reserved.
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- MEDICINE
- MEDICIN
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- ref (subject category)
- art (subject category)
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- Marchand, M
- Punt, CJA
- Aamdal, S
- Escudier, B
- Kruit, WHJ
- Keilholz, U
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- Håkansson, Leif
- van Baren, N
- Humblet, Y
- Mulders, P
- Avril, M-F
- Eggermont, AMM
- Scheibenbogen, C
- Uiters, J
- Wanders, J
- Delire, M
- Boon, T
- Stoter, G
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- Linköping University
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