Search: onr:"swepub:oai:DiVA.org:liu-25336" >
Progesterone and no...
Progesterone and norethisterone have different effects on tachykinin-like immunoreactivity in rat cortex and striatum
-
- Rugarn, Olof (author)
- Linköpings universitet,Obstetrik och gynekologi,Hälsouniversitetet
-
- Hammar, Mats, 1950- (author)
- Linköpings universitet,Obstetrik och gynekologi,Hälsouniversitetet
-
- Theodorsson, Elvar, 1953- (author)
- Linköpings universitet,Klinisk kemi,Hälsouniversitetet
-
(creator_code:org_t)
- 2001
- 2001
- English.
-
In: Regulatory Peptides. - 0167-0115 .- 1873-1686. ; 101:1-3, s. 87-91
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Objective: The purpose of this study was to investigate the effects of progesterone and the most commonly prescribed synthetic progestogen, norethisterone, on regional immune-like reactivity of neuropeptide Y (NPY), substance P (SP), neurokinin A (NKA) and neurotensin (NT) in brains of female ovariectomized estradiol-substituted rats.Results: Norethisterone+estradiol-treated rats had 44% lower SP levels compared with estradiol-only-treated in frontal cortex and 20% lower NKA levels in comparison with progesterone+estradiol-treated in frontal cortex. Progesterone+estradiol-treated rats had 66% lower SP levels in striatum in comparison with both estradiol-only-treated and norethisterone+estradiol-treated. No significant results were found for NPY and NT.Conclusion: Progesterone and the synthetic progestogen, norethisterone, have different effects on SP- and NKA-like immunoreactivity in rat cortex and striatum.The effects of NET on SP- and NKA-like immunoreactivity in frontal cortex may contribute to the mood effects ascribed to this progestogen in clinical usage.
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database