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Synthesis of inositol phosphoglycans containing thiol-terminated spacers for efficient coupling to maleimide functionalized solid phases or proteins
- Lindberg, Jan (author)
-
- Strålfors, Peter, 1951- (author)
- Linköpings universitet,Hälsouniversitetet,Cellbiologi
- Konradsson, Peter (author)
- (creator_code:org_t)
- 2002
- 2002
- English.
- In: Tetrahedron. - 0040-4020 .- 1464-5416. ; 58:21, s. 4245-4254
- Journal article (peer-reviewed)
Abstract
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- The synthesis of inositol phosphoglycans (IPGs), analogous to second messengers of insulin, to provide a small targeted library of compounds is described. These derivatives contain the glucosamine(a1-6)myo-inositol 1,2-cyclic phosphate motif. A thiol-terminated spacer was introduced, for their immobilization, by a radical elongation of an allyl ether with benzyl mercaptane. ⌐ 2002 Elsevier Science Ltd. All rights reserved.
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- MEDICIN
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