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NGF modulates CGRP ...
NGF modulates CGRP synthesis in human B-lymphocytes : A possible anti-inflammatory action of NGF?
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Bracci-Laudiero, Luisa (author)
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Aloe, Luigi (author)
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Buanne, Pasquale (author)
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- Finn, Anja (author)
- Karolinska Institutet
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Stenfors, Carina (author)
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Vigneti, Eliana (author)
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- Theodorsson, Elvar, 1953- (author)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Klinisk kemi
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Lundeberg, Thomas (author)
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(creator_code:org_t)
- 2002
- 2002
- English.
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In: Journal of Neuroimmunology. - 0165-5728 .- 1872-8421. ; 123:1-2, s. 58-65
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
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- We investigated whether the sensory neuropeptide, calcitonin gene-related peptide (CGRP), could be synthesised by human lymphocytes. Our results indicate that in activated B-cells, there is a strong expression of CGRP gene transcripts, which is almost absent in resting cells. Since B-cells autocrinally produce NGF, the neutralisation of endogenous NGF by anti-NGF antibodies resulted in a marked reduction in CGRP expression in both resting and activated B-cells. Thus, NGF appears to directly affect the synthesis of CGRP in B-cells as in sensory neurons. By regulating CGRP synthesis in lymphocytes and neuronal cells, NGF can influence the intensity and duration of the immune response. ⌐ 2002 Elsevier Science B.V. All rights reserved.
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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