onr:"swepub:oai:DiVA.org:liu-25849"
Search: onr:"swepub:oai:DiVA.org:liu-25849" > Do early childhood ...
- 1 of 1
- Previous record
- Next record
- To hitlist
- Grüber, C (author)
Do early childhood immunizations influence the development of atopy and do they cause allergic reactions?
- Article/chapterEnglish2001
Publisher, publication year, extent ...
- 2002-01-11
- Wiley,2001
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:liu-25849
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-25849URI
- https://doi.org/10.1034/j.1399-3038.2001.1r046.xDOI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:1932070URI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- Concerns about allergic side-effects of vaccines and about a possible promotion of allergic diseases contribute to incomplete vaccination rates in childhood. This article reviews the current understanding of these issues. There is evidence that pertussis and diphtheria/tetanus antigens elicit immunoglobulin E (IgE) antibody formation as part of the immune response. In murine models, pertussis toxin is an effective adjuvant for IgE formation against simultaneously administered antigens. In children, however, sensitization to unrelated antigens or development of allergic diseases do not seem to be augmented. In contrast, bacille Calmette-GuΘrin (BCG) and measles vaccination have been proposed as suppressors of allergy because of their T helper 1 (Th1)-fostering properties. In the murine system, BCG inhibits allergic sensitization and airway hyper-reactivity. Some epidemiological studies in humans suggest an inhibitory effect of tuberculosis on allergy. BCG vaccination in children, however, has no or merely a marginal suppressive effect on atopy. Other vaccine components such as egg proteins, gelatin, and antibiotics are a potential hazard to children with severe clinical reactions to these allergens. These rare children should be vaccinated under special precautions. In conclusion, vaccination programs do not explain the increasing prevalence of allergic diseases, but individual children may uncommonly develop an allergic reaction to a vaccine. The risks of not vaccinating children, however, far outweigh the risk for allergy. Therefore, childhood vaccination remains an essential part of child health programs and should not be withheld, even from children predisposed for allergy.
Subject headings and genre
- MEDICINE
- MEDICIN
Added entries (persons, corporate bodies, meetings, titles ...)
- Nilsson, Lennart,1954-Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Pediatrik,Barn(Swepub:liu)lenni67 (author)
- Björkstén, BengtKarolinska Institutet,Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Pediatrik,Barn (author)
- Linköpings universitetHälsouniversitetet (creator_code:org_t)
Related titles
- In:Pediatric Allergy and Immunology: Wiley12:6, s. 296-3110905-61571399-3038
Internet link
Find in a library
- Pediatric Allergy and Immunology (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Grüber, C
- Nilsson, Lennart ...
- Björkstén, Bengt
- Articles in the publication
- Pediatric Allerg ...
- By the university
- Linköping University
- Karolinska Institutet
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
