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Apolipoprotein A-I–...
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Mucchiano, Gerd I.Linköpings universitet,Molekylär och immunologisk patologi,Hälsouniversitetet
(author)
Apolipoprotein A-I–Derived Amyloid in Atherosclerosis : Its Association With Plasma Levels of Apolipoprotein A-I and Cholesterol
- Article/chapterEnglish2001
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LIBRIS-ID:oai:DiVA.org:liu-25965
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-25965URI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Wild-type apolipoprotein A-I (apo A-I)–derived amyloid commonly occurs in atherosclerotic plaques. To clarify apo A-I amyloid formation, plasma levels of apo A-I and cholesterol were related to the presence of amyloid in atherosclerotic plaques in 15 patients with peripheral atherosclerosis, subjected to arterial reconstruction. Plasma levels of apo A-I and high-density lipoprotein (HDL) cholesterol were slightly higher in patients with apo A-I–derived amyloid than in those without, but the difference was not significant. Levels of low-density lipoprotein cholesterol and total cholesterol were significantly higher in the group with amyloid. High concentrations of apo A-I in the arterial intima are probably of greater importance to amyloid formation than high plasma levels of the protein. During atherosclerosis, the acute phase reactant serum amyloid A may displace apo A-I from HDL, leading to increased concentration of lipid-free apo A-I in the intima and conformational changes of apo A-I, which make it more fibrillogenic. Some forms of amyloid fibrils have been shown to be cytotoxic. Apo AI–derived amyloid is possibly a pathogenically important factor in atherosclerosis.
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Jonasson, LenaDepartment of Medicine, Högland Hospital, Eksjö
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Häggqvist, Bo,1962-Linköpings universitet,Molekylär och immunologisk patologi,Hälsouniversitetet(Swepub:liu)boha34
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Einarsson, EibertDepartment of Surgery, Högland Hospital, Eksjö
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Westermark, PerLinköpings universitet,Molekylär och immunologisk patologi,Hälsouniversitetet
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Linköpings universitetMolekylär och immunologisk patologi
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Related titles
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In:American Journal of Clinical Pathology115, s. 298-3030002-91731943-7722
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