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Allergen-induced cy...
Allergen-induced cytokine secretion in atopic and non-atopic asthmatic children
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- Böttcher, Malin, 1969- (author)
- Linköpings universitet,Pediatrik,Hälsouniversitetet
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- Bjurström, Jenny (author)
- Linköpings universitet,Pediatrik,Hälsouniversitetet
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- Mai, Xiaomei, 1969- (author)
- Linköpings universitet,Pediatrik,Hälsouniversitetet
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- Nilsson, Lennart, 1954- (author)
- Östergötlands Läns Landsting,Linköpings universitet,Pediatrik,Barn,Hälsouniversitetet
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- Jenmalm, Maria, 1971- (author)
- Linköpings universitet,Pediatrik,Hälsouniversitetet
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(creator_code:org_t)
- 2003-10-23
- 2003
- English.
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In: Pediatric Allergy and Immunology. - : Wiley. - 0905-6157 .- 1399-3038. ; 14:5, s. 345-350
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Abstract
Subject headings
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- Atopic asthma is characterized by excessive T helper 2 (Th2)-like immunity to allergens in the bronchial mucosa. The Th2-cytokine interleukin (IL)-4 induces IgE production, while the Th2-cytokine IL-5 promotes eosinophilic inflammation in the airways of asthmatics. Most asthmatics are atopic, but a subgroup is non-atopic. We hypothesize that allergen-induced Th2, particularly IL-5, responses can be observed in peripheral blood in both atopic and non-atopic asthmatic children but not in healthy control children. The aim of the present study was to determine IL-4, IL-5, IL-9, IL-10, IL-13 and IFN-γ secretion induced from peripheral blood mononuclear cells (PBMC) by a broad panel of inhalant allergens (timothy, cat, birch, dog and house dust mite) in asthmatic children with and without sensitization. The study included 13 atopic asthmatic, 5 non-atopic asthmatic, and 12 non-atopic non-asthmatic children. PBMC were stimulated with allergens and cytokine production was measured with enzyme-linked immunosorbent assay (ELISA). Higher levels of cat and dog antigen-induced IL-5 release were more commonly observed in both atopic and non-atopic asthmatics than in controls. Children with atopic, but not non-atopic, asthma produced higher levels of allergen-induced IL-4 and IL-9 than controls. Non-atopic asthmatics produced more IL-10 than atopic asthmatics after cat stimulation. High levels of eosinophilia-associated IL-5 responses are induced by cat and dog allergen in both atopic and non-atopic asthmatic children. The Th2 cytokines IL-4 and IL-9 were associated only with atopic asthma, probably due to their IgE-inducing properties.
Keyword
- asthma
- atopy
- allergen
- childhood
- cytokines
- Th2
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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