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Detection and preve...
Detection and prevention of hepatitis C in dialysis patients and renal transplant recipients : A long-term follow up (1989–January 1997)
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- Almroth, Gabriel, 1953- (author)
- Linköpings universitet,Njurmedicin,Hälsouniversitetet
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- Ekermo, Bengt, 1952- (author)
- Linköpings universitet,Östergötlands Läns Landsting,Transfusionsmedicin och klinisk immunologi,Hälsouniversitetet
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- Månsson, Ann-Sofie (author)
- Lund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups,Department of Clinical Virology, University Hospital of Malmö, Sweden
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- Svensson, Samuel, 1962- (author)
- Linköpings universitet,Njurmedicin,Hälsouniversitetet
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- Widell, Anders (author)
- Lund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups,Department of Clinical Virology, University Hospital of Malmö, Sweden
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Svensson, G (author)
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(creator_code:org_t)
- Wiley, 2002
- 2002
- English.
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In: Journal of Internal Medicine. - : Wiley. - 0954-6820 .- 1365-2796. ; 251:2, s. 119-128
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Abstract
Subject headings
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- Background. Hepatitis C is frequent problem in dialysis wards.Design. A long time (1989–97) follow up of hepatitis C virus (HCV) infection in a Swedish nephrology unit was performed with anti-HCV screening, confirmatory antibody tests, viral RNA detection and molecular characterization. Case histories were reviewed with focus, onset of infection, liver morbidity and mortality.Results. In October 1991, 10% (19 of 184) of the patients in the unit (haemodialysis-, peritoneal dialysis and transplanted patients) were verified or suspected HCV carriers, whilst the number at the end of 1996 was 8% (13 of 157). Most patients were infected before 1991 but only in one case from a known HCV-infected blood donor. No new HCV infections associated with haemodialysis occurred during the study period. A total of 13 of 24 viremic patients had HCV genotype 2b, a pattern suggesting nosocomial transmission. This was further supported by phylogenetic analysis of HCV viral isolates in seven. HCV viremia was also common in patients with an incomplete anti-HCV antibody pattern as 8 of the 12 indeterminant sera were HCV-RNA positive.Conclusions. Awareness, prevention, identification of infected patients and donor testing limited transmission. Indeterminant recombinant immunoblot assays (RIBA)-results should be regarded with caution as a result of the relative immunodeficiency in uremic patients. Our data indicate nosocomial transmission in several patients.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Keyword
- dialysis
- hepatitis C virus
- polymerase chain reaction
- recombinant immunoblot assay
- transmission
- MEDICINE
- MEDICIN
- dialysis
- hepatitis C virus
- polymerase chain reaction
- transmission
- recombinant
- immunoblot assay
Publication and Content Type
- ref (subject category)
- art (subject category)
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