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Intravenous immunog...
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Darenberg, JKarolinska Institutet
(author)
Intravenous immunoglobulin G therapy in streptococcal toxic shock syndrome : A European randomized, double-blind, placebo-controlled trial
- Article/chapterEnglish2003
Publisher, publication year, extent ...
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Oxford University Press (OUP),2003
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:liu-26445
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-26445URI
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https://doi.org/10.1086/376630DOI
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https://lup.lub.lu.se/record/900117URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:1928004URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-65595URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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The efficacy and safety of high-dose intravenous polyspecific immunoglobulin G (IVIG) as adjunctive therapy in streptococcal toxic shock syndrome (STSS) were evaluated in a multicenter, randomized, double-blind, placebo-controlled trial. The trial was prematurely terminated because of slow patient recruitment, and results were obtained from 21 enrolled patients (10 IVIG recipients and 11 placebo recipients). The primary end point was mortality at 28 days, and a 3.6-fold higher mortality rate was found in the placebo group. A significant decrease in the sepsis-related organ failure assessment score at days 2 (P = .02) and 3 (P = .04) was noted in the IVIG group. Furthermore, a significant increase in plasma neutralizing activity against superantigens expressed by autologous isolates was noted in the IVIG group after treatment (P = .03). Although statistical significance was not reached in the primary end point, the trial provides further support for IVIG as an efficacious adjunctive therapy in STSS.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Ihendyane, N
(author)
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Sjölin, JUppsala universitet,Institutionen för medicinska vetenskaper,Infektion, Göran Friman
(author)
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Aufwerber, E
(author)
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Haidl, SvenLund University,Lunds universitet,Enheten för infektionssjukdomar,Forskargrupper vid Lunds universitet,Infectious Diseases Research Unit,Lund University Research Groups(Swepub:lu)inf-sha
(author)
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Follin, Per,1953-Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Infektionsmedicin,Infektionskliniken i Östergötland(Swepub:liu)perfo43
(author)
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Andersson, JKarolinska Institutet
(author)
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Norrby-Teglund, AKarolinska Institutet
(author)
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Streptlg Study, Group
(author)
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Karolinska InstitutetInstitutionen för medicinska vetenskaper
(creator_code:org_t)
Related titles
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In:Clinical Infectious Diseases: Oxford University Press (OUP)37, s. 333-1058-48381537-6591
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In:Clin Infect Dis: Oxford University Press (OUP)37, s. 333-
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Darenberg, J
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Ihendyane, N
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Sjölin, J
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Aufwerber, E
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Haidl, Sven
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Follin, Per, 195 ...
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Andersson, J
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Norrby-Teglund, ...
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Clinical Infecti ...
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Linköping University
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Lund University
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Karolinska Institutet
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