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Sökning: onr:"swepub:oai:DiVA.org:liu-26554" > Analysis of PorA va...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03274naa a2200385 4500 | |
| 001 | oai:DiVA.org:liu-26554 | |
| 003 | SwePub | |
| 008 | 091008s2003 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-265542 URI |
| 024 | 7 | a https://doi.org/10.1016/S0264-410X(03)00033-12 DOI |
| 040 | a (SwePub)liu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Clarke, S. C.u Scottish Meningococcus and Pneumococcus Reference Laboratory, North Glasgow University Hospitals NHS Trust, Stobhill Hospital, Scotland, UK and Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow, Scotland, UK4 aut |
| 245 | 1 0 | a Analysis of PorA variable region 3 in meningococci :b implications for vaccine policy? |
| 264 | 1 | c 2003 |
| 338 | a print2 rdacarrier | |
| 520 | a Outer membrane protein (OMP) vaccines are being developed against Neisseria meningitidis serogroup B which may provide protection against common circulating serotypes and serosubtypes in some countries. However, limited data is available in Europe from genosubtyping meningococci. We therefore undertook a retrospective analysis of the three main variable regions, VR1, VR2 as well as VR3, of the porA gene from N. meningitidis isolated from different countries, mainly from Scotland and Sweden. Analysis of this gene showed that, amongst 226 strains studied, there were a total of 78 different strains. No new VR1 or VR2 alleles were found but five new VR3 alleles are described. Our data indicates the importance of analysing the VR3 region of PorA in addition to VR1 and VR2 and also highlights, in general terms, the need for genosubtyping meningococci. Such analyses have major implications for the design of new meningococcal vaccines. | |
| 653 | a Neisseria meningitidis | |
| 653 | a Meningococci | |
| 653 | a porA | |
| 653 | a Sequence typing | |
| 653 | a Vaccine | |
| 653 | a MEDICINE | |
| 653 | a MEDICIN | |
| 700 | 1 | a Diggle, M. A.u Scottish Meningococcus and Pneumococcus Reference Laboratory, North Glasgow University Hospitals NHS Trust, Stobhill Hospital, Scotland, UK4 aut |
| 700 | 1 | a Mölling, Paulau National Reference Laboratory for Pathogenic Neisseria, Örebro University Hospital, Örebro, Sweden4 aut |
| 700 | 1 | a Unemo, Magnus,d 1970-u National Reference Laboratory for Pathogenic Neisseria, Örebro University Hospital, Örebro, Sweden4 aut0 (Swepub:liu)magun79 |
| 700 | 1 | a Olcén, Per,d 1943-u National Reference Laboratory for Pathogenic Neisseria, Örebro University Hospital, Örebro, Sweden4 aut0 (Swepub:liu)perol69 |
| 710 | 2 | a Scottish Meningococcus and Pneumococcus Reference Laboratory, North Glasgow University Hospitals NHS Trust, Stobhill Hospital, Scotland, UK and Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow, Scotland, UKb Scottish Meningococcus and Pneumococcus Reference Laboratory, North Glasgow University Hospitals NHS Trust, Stobhill Hospital, Scotland, UK4 org |
| 773 | 0 | t Vaccineg 21:19-20, s. 2468-2473q 21:19-20<2468-2473x 0264-410Xx 1873-2518 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-26554 |
| 856 | 4 8 | u https://doi.org/10.1016/S0264-410X(03)00033-1 |
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