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Therapeutic drug mo...
Therapeutic drug monitoring of sertraline : Variability factors as displayed in a clinical setting
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- Lundmark, Jöns, 1953- (author)
- Linköpings universitet,Psykiatri,Hälsouniversitetet
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- Reis, Margareta, 1959- (author)
- Linköpings universitet,Psykiatri,Klinisk farmakologi,Hälsouniversitetet
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- Bengtsson, Finn, 1956- (author)
- Linköpings universitet,Psykiatri,Klinisk farmakologi,Hälsouniversitetet
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(creator_code:org_t)
- Ovid Technologies (Wolters Kluwer Health), 2000
- 2000
- English.
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In: Therapeutic Drug Monitoring. - : Ovid Technologies (Wolters Kluwer Health). - 0163-4356 .- 1536-3694. ; 22:4, s. 446-454
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- This report describes sertraline pharmacokinetics derived from routine therapeutic drug monitoring (TDM) data. A high-performance liquid chromatographic method with ultraviolet detection was established for routine sertraline TDM, and 924 analyses were performed from April 1995 to May 1997. Extensive predefined inclusion/exclusion criteria were applied to increase the validity of scientifically evaluated data. Subsequently, 605 samples (65.5%) were excluded. The remaining 319 samples from 319 patients, representative of steady state through specimens and accompanied by essential clinical information provided on request forms, were scrutinized. A pronounced interindividual variability was observed. Smokers had significantly lower concentration-to-dose (C/D) mean ratios of serum sertraline (s-sert) and its main metabolite desmethylsertraline (s-dsert) than nonsmokers. Higher s-sert and s-dsert C/D mean ratios were found in elderly patients than in adults aged less than 65 years. In a subset of 20 patients in whom repeated TDM analyses were performed, observed intraindividual sertraline TDM outcome variability was low. The results highlight sertraline TDM as a tool for individual dose optimization and evaluation of patient drug compliance as well as drug-drug interactions.
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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