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Therapeutic drug mo...
Therapeutic drug monitoring of selective serotonin reuptake inhibitors influences clinical dosing strategies and reduces drug costs in depressed elderly patients
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- Lundmark, Jöns, 1953- (författare)
- Linköpings universitet,Psykiatri,Hälsouniversitetet
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- Bengtsson, Finn, 1956- (författare)
- Linköpings universitet,Psykiatri,Klinisk farmakologi,Hälsouniversitetet
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- Nordin, Conny, 1944- (författare)
- Linköpings universitet,Psykiatri,Hälsouniversitetet
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- Reis, Margareta, 1959- (författare)
- Linköpings universitet,Klinisk farmakologi,Hälsouniversitetet
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- Wålinder, Jan (författare)
- Linköpings universitet,Psykiatri,Hälsouniversitetet
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(creator_code:org_t)
- 2001-12-24
- 2000
- Engelska.
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Ingår i: Acta Psychiatrica Scandinavica. - : Wiley. - 0001-690X .- 1600-0447. ; 101:5, s. 354-359
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Objective: This study was initiated in order to describe and evaluate the effects of a therapeutic drug monitoring (TDM) routine of selective serotonin reuptake inhibitors (SSRIs) on treatment strategies and drug costs in depressed elderly patients.Method: Blood samples were drawn from elderly depressed patients and analysed for steady-state trough serum concentrations of citalopram (n=48), paroxetine (n=48) or sertraline (n=39). A global efficacy evaluation was made at baseline and after 6–9 months. Antidepressant drug costs before and after TDM were estimated.Results: Eight samples were excluded due to technical problems or non-compliance. In 65 of the 127 (51.2%) remaining cases, the treatment strategy was changed according to the TDM outcome, in most a reduction of the prescribed dose. Bioanalytical TDM costs included the antidepressant drug costs after TDM were reduced by 10.2%.Conclusion: The results support the utility of TDM in the search for the individual minimum effective SSRI dose in the elderly.
Nyckelord
- antidepressants
- serotonin uptake inhibitors
- pharmacokinetics
- pharmaceutical economics
- depression
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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