onr:"swepub:oai:DiVA.org:liu-27841"
Search: onr:"swepub:oai:DiVA.org:liu-27841" > Adenoid cystic carc...
- 1 of 1
- Previous record
- Next record
- To hitlist
- Norberg-Spaak, LenaÖstergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Oto-Rhino-Laryngologi,ÖNH - Öron- Näsa- Halskliniken (author)
Adenoid cystic carcinoma : Use of cell proliferation, bcl-2 expression, histologic grade, and clinical stage as predictors of clinical outcome
- Article/chapterEnglish2000
Publisher, publication year, extent ...
- 2000
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:liu-27841
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-27841URI
- https://doi.org/10.1002/1097-0347(200008)22:5<489::AID-HED8>3.0.CO;2-XDOI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- Background. Although the three basic histologic growth patterns of adenoid cystic carcinomas (tubular, cribriform, and solid) provide some indication of clinical outcome, additional, perhaps superior, predictors of biologic activity are needed for patient management. Methods. This series is composed of 31 adenoid cystic carcinomas that presented in Linkoping between 1982 and 1997. The tumors were clinically staged and histologically graded. For each case, after immunohistochemical identification, the proportion of tumor cells expressing the cell cycle markers MIB-1 and bcl-2 (as an indicator of proliferation and apoptosis, respectively) were quantified. Statistical correlation was sought between tumor stage and grade and the two cell cycle markers. Results. The proportions of cycling tumor cells in adenoid cystic carcinomas ranged from 0.3% to 55%. For patients with no evidence of disease and a follow-up of at least 5 years, the mean percent MIB-1 value was significantly lower than for those patients who were alive with local recurrence and/or metastasis or who had died from their adenoid cystic carcinoma (p = .024). MIB-1 tumor cell positivity also correlated strongly with tumor grade (p = .053), but not with stage (p = .22). Neither clinical stage nor histologic grade correlated with the degree of bcl-2 tumor cell positivity (p = .97 and p = .49, respectively). Conclusions. Staging and grading continue to play a vital role in the management of patients with adenoid cystic carcinoma. Furthermore, in this series of patients with adenoid cystic carcinoma, a cycling tumor cell population as measured by the MIB-1 antibody greater than 10% indicates this group as biologically more aggressive and at an increased risk for a fatal course. (C) 2000 John Wiley and Sons, Inc.
Subject headings and genre
- MEDICINE
- MEDICIN
Added entries (persons, corporate bodies, meetings, titles ...)
- Norberg-Spaak, LenaÖstergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Oto-Rhino-Laryngologi,ÖNH - Öron- Näsa- Halskliniken (author)
- Dardick, Irving (author)
- Dardick, I. (author)
- Ledin, Torbjörn,1962-Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Oto-Rhino-Laryngologi,ÖNH - Öron- Näsa- Halskliniken(Swepub:liu)torle18 (author)
- Linköpings universitetHälsouniversitetet (creator_code:org_t)
Related titles
- In:Head and Neck22:5, s. 489-4971043-30741097-0347
Internet link
Find in a library
- Head and Neck (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Norberg-Spaak, L ...
- Dardick, Irving
- Dardick, I.
- Ledin, Torbjörn, ...
- Articles in the publication
- Head and Neck
- By the university
- Linköping University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
