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Gaba transporters (...
Gaba transporters (GAT-1) in Alzheimer´s disease.
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- Nägga, Katarina, 1962- (author)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Geriatrik,Geriatrik-LAH
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Bogdanovic, N. (author)
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- Marcusson, Jan, 1958- (author)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Geriatrik,Geriatrik-LAH
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(creator_code:org_t)
- 1999
- 1999
- English.
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In: Journal of neural transmission. - 0300-9564 .- 1435-1463. ; 106:11-12, s. 1141-1149
- Related links:
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https://urn.kb.se/re...
Abstract
Subject headings
Close
- The presynaptically located gamma-aminobutyric acid (GABA) transporter (GAT-1) was studied in a group of patients with Alzheimer's disease (AD) and in a control group using the GAT-1 selective radioligand [H-3]tiagabine. Post mortem brain tissue from frontal cortex, temporal cortex, and caudate nucleus from 18 AD patients and 23 age-matched controls were studied. The binding was saturable (Kd 26 nM) and region specific. There were no significant differences between the groups with respect to the binding capacity (Bmax) and binding affinity (Kd). The unaltered [H-3]tiagabine binding to GAT-1 protein indicates that intrinsic GABA neurons are spared in Alzheimer's disease.
Keyword
- GAT-1
- GABA transporters
- Alzheimer's disease
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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