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Acidosis in muscle ...
Acidosis in muscle tissue distal to vascular contusion despite unchanged global blood flow in rats : An uncoupling of microvascular blood flow and metabolism?
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- Karlander, Lars-Erik, 1950- (author)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Avdelningen för kirurgi,Hand- och plastikkirurgiska kliniken US
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- Henriksson, J (author)
- Karolinska Institutet
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- Sjöberg, Folke, 1956- (author)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Avdelningen för kirurgi,Hand- och plastikkirurgiska kliniken US
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(creator_code:org_t)
- Elsevier BV, 2005
- 2005
- English.
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In: Microvascular Research. - : Elsevier BV. - 0026-2862 .- 1095-9319. ; 70:1-2, s. 111-115
- Related links:
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https://urn.kb.se/re...
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Abstract
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- Studies using a contusion trauma model have shown that the femoral artery of the rat remains patent in 85% despite a severe vessel injury. A significant increase in tissue oxygenation (PtO2) has been found despite only a minor effect on blood flow (<20% decrease) on the muscle surface distal to the injury indicating a disturbed relationship between microvascular blood flow and metabolism. The aim of the present study was to further study the interplay between microvascular blood flow and metabolism within the distal muscle using an ethanol clearance technique (blood flow) in conjunction to the determination of an ischemia marker (lactate) by use of microdialysis. Although skeletal muscle blood flow remained unaltered as assessed by ethanol clearance, skeletal muscle lactate levels increased significantly (P < 0.001) post-trauma in both legs. The increase was initially higher, faster and the increase over time larger in the trauma leg as compared to the control leg (P < 0.001). These findings indicate a systemic effect of the trauma. Further, it suggests a functional impairment of the relationship between microvascular blood flow and/or muscle metabolic processes when the trauma is directed towards the supplying blood vessel. The reason for this anaerobic insult as found in this study compared to the presence of a local increase in PtO2 in the trauma leg as shown in our previous study is suggestive of an microvascular blood flow and tissue metabolism uncoupling. © 2005 Elsevier Inc. All rights reserved.
Keyword
- blood flow
- blunt trauma
- ethanol clearance
- lactate
- microdialysis
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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