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In vitro Th2 deviat...
In vitro Th2 deviation of myelin-specific peripheral blood lymphocytes from patients with multiple sclerosis
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- Hallin, Elisabeth, 1980- (author)
- Linköpings universitet,Hälsouniversitetet,Klinisk immunologi
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- Mellergård, Johan, 1974- (author)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Neurologi,Neurologiska kliniken
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- Vrethem, Magnus, 1955- (author)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Neurologi,Neurologiska kliniken
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- Ernerudh, Jan, 1952- (author)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Klinisk immunologi,Klinisk immunologi och transfusionsmedicin
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- Ekerfelt, Christina, 1957- (author)
- Linköpings universitet,Hälsouniversitetet,Klinisk immunologi
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(creator_code:org_t)
- Elsevier BV, 2006
- 2006
- English.
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In: Journal of Neuroimmunology. - : Elsevier BV. - 0165-5728 .- 1872-8421. ; 171:1-2, s. 156-162
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- This study aimed at investigating if selective ex vivo immune deviation of myelin-specific cytokine secretion towards Th2 is possible in blood cells from patients with multiple sclerosis (MS). Interleukin (IL)-4 (Th2) and interferon-γ (Th1) secreting cells were recorded by ELISPOT in 13 MS patients. Deviation was successful in 10 patients. Interleukin-4 alone was most effective in inducing myelin-specific immune deviation in MS patients whereas IL-1 or IL-15 in combination with IL-4 did not improve the results. Further studies and improvements are needed before ex vivo immune deviation can be considered a potential treatment in patients with MS. © 2005 Elsevier B.V. All rights reserved.
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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