Resveratrol induces apoptosis and inhibits angiogenesis in human breast cancer xenografts in vivo

• Resveratrol, a polyphenol found in grapes and wine, is considered a potential cancer chemopreventive agent. Resveratrol has been shown to induce transcription via both ERα and ERβ. We observed significantly lower tumor growth, decreased angiogenesis, and increased apoptotic index in ERα- ERβ+ MDA-MB-231 tumors in resveratrol-treated nude mice compared with controls. In vitro we found a significant increase in apoptosis in resveratrol-treated MDA-MB-231 cells in addition to significantly reduced extracellular levels of VEGF. This study supports the potential use of resveratrol as a chemotherapeutic agent in breast cancers. © 2005 Elsevier Ireland Ltd. All rights reserved.

Keyword

Angiogenesis; Apoptosis; MDA-MB-231; Vascular endothelial growth factor

VEGF

MEDICINE

MEDICIN

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ref (subject category)

art (subject category)