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Impaired transport ...
Impaired transport as a mechanism of resistance to thiopurines in human T-lymphoblastic leukemia cells
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- Fotoohi, Alan Kambiz (author)
- Karolinska Institutet
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- Lindqvist Appell, Malin, 1976- (author)
- Linköpings universitet,Hälsouniversitetet,Klinisk farmakologi
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- Peterson, Curt, 1944- (author)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Klinisk farmakologi
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- Albertioni, Freidoun (author)
- Karolinska Institutet
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(creator_code:org_t)
- Informa UK Limited, 2006
- 2006
- English.
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In: Nucleosides, Nucleotides & Nucleic Acids. - : Informa UK Limited. - 1525-7770 .- 1532-2335. ; 25:9-11, s. 1039-1044
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- In order to better understand the mechanisms of resistance to thiopurines, we studied two sublines of the MOLT4 T-lymphoblastic leukemia cell line, resistant to 6-mercaptopurine (6-MP) and 6-thioguanine (6-TG). We found that the underlying mechanism of resistance in both resistant cell lines was a markedly reduction in initial transport of 6-MP (3- and 5-fold, respectively, in 6-MP- and 6-TG-resistant cells). No significant alteration of activities of hypoxanthine-guanine phosphoribosyl transferase, thiopurine methyltransferase or inosine monophosphate dehydrogenase, the key enzymes involved in the metabolism of thiopurines was detected. We conclude that defected initial transport of thiopurines by cells may very well explain their resistance to these drugs. Copyright © Taylor & Francis Group, LLC.
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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