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Clinicopathological...
Clinicopathological significance of stromal variables : Angiogenesis, lymphangiogenesis, inflammatory infiltration, MMP and PINCH in colorectal carcinomas
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- Sun, Xiao-Feng, 1959- (author)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Onkologi,Onkologiska kliniken US
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- Zhang, Hong, 1957- (author)
- Linköpings universitet,Hälsouniversitetet,Avdelningen för dermatologi och venereologi
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(creator_code:org_t)
- Springer Science and Business Media LLC, 2006
- 2006
- English.
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In: Molecular Cancer. - : Springer Science and Business Media LLC. - 1476-4598. ; 5
- Related links:
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https://molecular-ca...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Cancer research has mainly focused on alterations of genes and proteins in cancer cells themselves that result in either gain-of-function in oncogenes or loss-of-function in tumour-suppressor genes. However, stromal variables within or around tumours, including blood and lymph vessels, stromal cells and various proteins, have also important impacts on tumour development and progression. It has been shown that disruption of stromal-epithelial interactions influences cellular proliferation, differentiation, death, motility, genomic integrity, angiogenesis, and other phenotypes in various tissues. Moreover, stromal variables are also critical to therapy in cancer patients. In this review, we mainly focus on the clinicopathological significance of stromal variables including angiogenesis, lymphangiogenesis, inflammatory infiltration, matrix metalloproteinase (MMP), and the particularly interesting new cysteine-histidine rich protein (PINCH) in colorectal cancer (CRC). © 2006 Sun and Zhang, licensee BioMed Central Ltd.
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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