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Radiotherapy respon...
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Roberg, Karin,1957-Linköpings universitet,Oto-Rhino-Laryngologi,Hälsouniversitetet
(author)
Radiotherapy response in oral squamous carcinoma cell lines : Evaluation of apoptotic proteins as prognostic factors
- Article/chapterEnglish2007
Publisher, publication year, extent ...
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2007
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Wiley,2007
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:liu-39259
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-39259URI
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https://doi.org/10.1002/hed.20520DOI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Background. In this study, we investigated the importance of apoptosis for cell death after radiotherapy, and whether the expression of pro- and anti-apoptotic proteins has any correlation to the radiosensitivity.Methods. Three oral squamous cell carcinoma cell lines, UT-SCC-2, UT-SCC-9 and UT-SCC-24A, were subjected to radiotherapy. After irradiation, viable and dead cells were counted to determine radiation sensitivity and apoptosis was analyzed by measurement of caspase-3 activity. The expressions of pro- and anti-apoptotic proteins were assessed using western blot analyses.Results and Conclusion. After irradiation, apoptotic morphology and caspase-3 activity were only detected in cell lines exhibiting high or moderate radiosensitivity. Western blot analysis indicates that survivin, epidermal growth factor receptor, cyclooxygenase-2, and Bcl-xL are critical components in irradiation resistance of the investigated cell lines. Moreover, our results suggest that apoptotic cell death and the balance between pro- and anti-apoptotic proteins are of importance for the outcome of radiotherapy.
Subject headings and genre
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Apoptosis; oral tumors; predictive markers; radiotherapy; radiosensitivity
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MEDICINE
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MEDICIN
Added entries (persons, corporate bodies, meetings, titles ...)
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Jonsson, Ann-CharlotteLinköpings universitet,Medicinsk radiofysik,Hälsouniversitetet(Swepub:liu)annjo32
(author)
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Grénman, ReidarDepartment of Otorhinolaryngology, Head and Neck Surgery, Central Hospital and University of Turku and Medical Biochemistry, University of Turku, Finland
(author)
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Norberg-Spaak, Lena,1956-Linköpings universitet,Oto-Rhino-Laryngologi,Hälsouniversitetet(Swepub:liu)lenno72
(author)
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Linköpings universitetOto-Rhino-Laryngologi
(creator_code:org_t)
Related titles
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In:Head and Neck: Wiley29:4, s. 325-3341043-30741097-0347
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