onr:"swepub:oai:DiVA.org:liu-39382"
Search: onr:"swepub:oai:DiVA.org:liu-39382" > Low plasma levels o...
- 1 of 1
- Previous record
- Next record
- To hitlist
Low plasma levels of oxygenated carotenoids in patients with coronary artery disease
-
- Lidebjer, Caroline, 1979- (author)
- Linköpings universitet,Yrkes- och miljömedicin,Hälsouniversitetet
-
- Leanderson, Per, 1958- (author)
- Östergötlands Läns Landsting,Linköpings universitet,Yrkes- och miljömedicin,Hälsouniversitetet,Yrkes- och miljömedicinskt centrum
-
- Ernerudh, Jan, 1952- (author)
- Östergötlands Läns Landsting,Linköpings universitet,Klinisk immunologi,Hälsouniversitetet,Klinisk immunologi och transfusionsmedicin
- show more...
- show less...
- (creator_code:org_t)
- Elsevier BV, 2007
- 2007
- English.
- In: NMCD. Nutrition Metabolism and Cardiovascular Diseases. - : Elsevier BV. - 0939-4753 .- 1590-3729. ; 17:6, s. 448-456
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Background and aims: Low circulating levels of carotenoids have been associated with cardiovascular disease. The distribution of different carotenoids in blood may have an impact on the cardioprotective capacity. The aim of the present study was to determine the plasma levels of 6 major carotenoids in patients with coronary artery disease (CAD) and relate the findings to clinical, metabolic and immune parameters. Methods and results: Plasma levels of oxygenated carotenoids (lutein, zeaxanthin, β-cryptoxanthin) and hydrocarbon carotenoids (α-carotene, β-carotene, lycopene) were determined in 39 patients with acute coronary syndrome, 50 patients with stable CAD and 50 controls. Serological assays for inflammatory activity and flow cytometrical analysis of lymphocyte subsets were performed. Both patient groups had significantly lower plasma levels of oxygenated carotenoids, in particular lutein + zeaxanthin, compared to controls. Low levels of oxygenated carotenoids were associated with smoking, high body mass index (BMI), low high density lipoprotein (HDL) cholesterol and, to a minor degree, inflammatory activity. Plasma levels of lutein + zeaxanthin were independently associated with the proportions of natural killer (NK) cells, but not with other lymphocytes, in blood. Conclusion: Among carotenoids, lutein + zeaxanthin and β-cryptoxanthin were significantly reduced in CAD patients independent of clinical setting. The levels were correlated to a number of established cardiovascular risk factors. In addition, the relationship between NK cells and lutein + zeaxanthin may indicate a particular role for certain carotenoids in the immunological scenario of CAD. © 2006 Elsevier B.V. All rights reserved.
Keyword
- oxygenated
- carotenoids
- coronary artery
- disease
- Lutein + zeaxanthin
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- NMCD. Nutrition Metabolism and Cardiovascular Diseases (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Lidebjer, Caroli ...
- Leanderson, Per, ...
- Ernerudh, Jan, 1 ...
- Jonasson, Lena, ...
- Articles in the publication
- NMCD. Nutrition ...
- By the university
- Linköping University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
