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Novel mutations and...
Novel mutations and sequence variants in exons 3-9 of human T Cell Factor-4 gene in sporadic rectal cancer patients stratified by microsatellite instability
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Meng, Wen-Jian (author)
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Wang, Ling (author)
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Tian, Chao (author)
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Yu, Yong-Yang (author)
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Zhou, Beng (author)
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Gu, Yun (author)
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Xia, Qing-Jie (author)
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- Sun, Xiao-Feng, 1959- (author)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Onkologi,Onkologiska kliniken US
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Li, Yuan (author)
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Wang, Rong (author)
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Zheng, Xue-Lian (author)
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Zhou, Zong-Guang (author)
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(creator_code:org_t)
- 2007
- 2007
- English.
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In: World Journal of Gastroenterology. - 1007-9327 .- 2219-2840. ; 13:27, s. 3747-3751
- Related links:
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https://urn.kb.se/re...
Abstract
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- Aim: To establish the role of human T Cell Factor-4 (hTCF-4) gene exons 3-9 mutation status in association with sporadic rectal cancer with microsatellite instability (MSI). Methods: Microsatellite markers were genotyped in 93 sporadic rectal cancer patients. Eleven cases were found to be high-frequency MSI (MSI-H). Sequence analysis of the coding region of the exons 3-9 of hTCF-4 gene was carried out for the 11 MSI-H cases and 10 controls (5 microsatellite stability (MSS) cases and 5 cases with normal mucosa). The sequencing and MSI identification were used. Results: Several novel mutations and variants were revealed. In exon 4, one is a 4-position continuous alteration which caused amino acid change from Q131T and S132I (391insA, 392 G > A, 393 A > G and 395delC) and another nucleotide deletion (395delC) is present in MSI-H cases (5/10 and 4/10, respectively) but completely absent in the controls. Conclusion: Novel mutations in exon 4 of hTCF-4 gene were revealed in this study, which might be of importance in the pathogenesis of sporadic rectal cancer patients with MSI-H. © 2007 WJG. All rights reserved.
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- By the author/editor
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Meng, Wen-Jian
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Wang, Ling
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Tian, Chao
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Yu, Yong-Yang
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Zhou, Beng
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Gu, Yun
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show more...
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Xia, Qing-Jie
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Sun, Xiao-Feng, ...
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Li, Yuan
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Wang, Rong
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Zheng, Xue-Lian
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Zhou, Zong-Guang
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show less...
- Articles in the publication
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World Journal of ...
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Linköping University