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IgA endomysium anti...
IgA endomysium antibodies : an early predictor for celiac disease in children without villous atrophy
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- Grodzinsky, Ewa, 1958- (author)
- Linköpings universitet,Östergötlands Läns Landsting,Forsknings- och utvecklingsenheten för Närsjukvården i Östergötland,Hälsouniversitetet
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- Fälth-Magnusson, Karin, 1949- (author)
- Linköpings universitet,Pediatrik,Hälsouniversitetet
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- Högberg, Lotta, 1960- (author)
- Norrköping Hospital, Norrköping, Sweden
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- Jansson, Gunnar (author)
- Motala Hospital, Motala, Sweden
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- Laurin, Pia, 1969- (author)
- Linköpings universitet,Pediatrik,Hälsouniversitetet
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- Stenhammar, Lars, 1939- (author)
- Linköpings universitet,Pediatrik,Hälsouniversitetet
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(creator_code:org_t)
- Wiley, 2008
- 2008
- English.
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In: Acta Paediatrica. - : Wiley. - 0803-5253 .- 1651-2227. ; 97:7, s. 972-976
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Aim: To evaluate possible differences between children with anti-endomysium antibodies (EMA) positivity and normal small bowel mucosa and children with positive EMA and an enteropathy diagnosed as celiac disease (CD).Methods: Children with suspected CD and positive EMA (≥1/10) undergoing small bowel biopsy during 1996 to 2002, were investigated (n = 133). Data registered were: year and month of birth, timing of the first biopsy, sex, heredity for CD, dermatitis herpetiformis and diabetes mellitus and outcome of the anti-gliadin antibody test (AGA). The case group, with EMA positivity and normal histology (n = 39; 59% female, mean age at the first biopsy 7.3 years, range 1.4–16), was compared with the disease control group, with positive EMA and a biopsy suggestive and further on diagnosed as CD (n = 94; 56% female; mean age 7.6 years at the first biopsy, range 0.70–17).Results: AGA positivity and heredity for CD were found to predict the outcome of a pathological jejunal mucosa. Nineteen of the 39 children in the case group were rebiopsied of whom 11 had developed an enteropathy during a follow-up period of 2–7 years (median 4.5 years).Conclusions: EMA positivity in the absence of small bowel enteropathy could be a very early predictor for later overt CD, and necessitates further follow-up, especially if the child is AGA positive and there is a family history of CD.
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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