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Legionella pneumoph...
Legionella pneumophila serogroup 1 antibody kinetics in patients with Legionnaires' disease : implications for serological diagnosis
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- Darelid, Johan (author)
- Department of Infectious Diseases, Ryhov Hospital, Jönköping, Sweden
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- Löfgren, Sture (author)
- Department of Clinical Bacteriology, Ryhov Hospital, Jönköping, Sweden
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- Malmvall, Bo-Eric (author)
- Department of Infectious Diseases, Ryhov Hospital, Jönköping, Sweden
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- Olinder-Nielsen, Ann-Margareth (author)
- Department of Infectious Diseases, Ryhov Hospital, Jönköping, Sweden
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- Briheim, Gunnar (author)
- Linköpings universitet,Infektionsmedicin,Hälsouniversitetet
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- Hallander, H. (author)
- Swedish Inst. Infect. Dis. Control, Stockholm, Sweden
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(creator_code:org_t)
- 2009-07-08
- 2003
- English.
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In: Scandinavian Journal of Infectious Diseases. - : Informa UK Limited. - 0036-5548 .- 1651-1980. ; 35:1, s. 15-20
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- To evaluate current serological criteria for Legionella pneumophila serogroup 1 (Lp1), the antibody response was prospectively studied in all patients hospitalized for Legionnaires' disease in a Swedish county during 11 y (n = 62). A 4-fold or greater rise in antibody titre to ≥ 128 (the minimum convalescent antibody level for diagnosis, as recommended by the Centers for Disease Control and Prevention), using the indirect immunofluorescence antibody test, was found in 21/52 (40%) of tested patients. By referring to the titre levels in healthy residents from the local population (World Health Organization criteria), 45/52 (87%) cases were confirmed serologically. In 21 patients followed longitudinally for 10 y, the median antibody titre fell from 256 (range 32-1024) to 16 (range 2-128) in 3 y. No booster reactions were observed in any patient. After 10 y, the geometric mean titre of this clinical cohort had reached the same level as observed in the background population 5 y earlier. Titre levels in subjects exposed to Legionella from a municipal water system indicate that only 1 out of 10 of all infections are identified clinically. Indirect immunofluorescent antibody testing with local reference sera is a sensitive method for laboratory confirmation of Lp1 in an unselected pneumonia population.
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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