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FLT3 mutations in a...
FLT3 mutations in a 10 year consecutive series of 177 childhood acute leukemias and their impact on global gene expression patterns
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- Andersson, A. (author)
- Department of Clinical Genetics, University Hospital, Lund, Sweden, Department of Clinical Genetics, University Hospital, SE-221 85 Lund, Sweden
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- Paulsson, K. (author)
- Department of Clinical Genetics, University Hospital, Lund, Sweden, Cancer Research UK Medical Oncology Centre, Barts and The Royal London School of Medicine, Queen Mary College, London, United Kingdom
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- Lilljebjorn, H. (author)
- Lilljebjörn, H., Department of Clinical Genetics, University Hospital, Lund, Sweden
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- Lassen, C. (author)
- Department of Clinical Genetics, University Hospital, Lund, Sweden
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- Strombeck, B. (author)
- Strömbeck, B., Department of Clinical Genetics, University Hospital, Lund, Sweden
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- Heldrup, J. (author)
- Department of Pediatrics, University Hospital, Lund, Sweden
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- Behrendtz, Mikael (author)
- Östergötlands Läns Landsting,Barn- och ungdomskliniken i Linköping
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- Johansson, B. (author)
- Department of Clinical Genetics, University Hospital, Lund, Sweden
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- Fioretos, T. (author)
- Department of Clinical Genetics, University Hospital, Lund, Sweden
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(creator_code:org_t)
- Wiley, 2008
- 2008
- English.
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In: Genes, Chromosomes and Cancer. - : Wiley. - 1045-2257 .- 1098-2264. ; 47:1, s. 64-70
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- During 1995-2004, 209 children/adolescents were diagnosed with acute lymphoblastic or myeloid leukemia (ALL, AML) in Southern Sweden, of which 177 (85%), comprising 128 B-lineage ALL, 34 AML, and 15 T-cell ALL, could be analyzed for internal tandem duplications (ITD) and activating point mutations in the second tyrosine kinase domain (ATKD) of FLT3. Seventeen (10%) FLT3 mutations (6 ITD, 11 ATKD, mutually exclusive) were detected. None of the T-cell ALL harbored any mutations. ITD and ATKD were found in 2% and 6% of the B-lineage ALL and in 12% and 9% of the AML, being particularly common in high hyperdiploid ALL (14%), ALL (20%), and AML (23%) with 11q23/MLL rearrangements, and in AML with a normal karyotype (60%). All ATKD-positive AML with MLL rearrangements harbored the t(9,11)(p21,q23). Global gene expression data were available for 76 of the B-lineage ALL and 19 of the AML, of which 6 (8%) and 3 (16%) had FLT3 mutations, respectively. No distinct expression pattern associated with FLT3 mutations was identified. © 2007 Wiley-Liss, Inc.
Keyword
- NATURAL SCIENCES
- NATURVETENSKAP
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Andersson, A.
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Paulsson, K.
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Lilljebjorn, H.
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Lassen, C.
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Strombeck, B.
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Heldrup, J.
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Behrendtz, Mikae ...
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Johansson, B.
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Fioretos, T.
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- Articles in the publication
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Genes, Chromosom ...
- By the university
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Linköping University