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Increased Prevalenc...
Increased Prevalence of Anti-Gliadin IgA-Antibodies with Aberrant Duodenal Histopathological Findings in Patients with IgA-Nephropathy and Related Disorders
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- Almroth, Gabriel (author)
- Linköpings universitet,Njurmedicin,Hälsouniversitetet
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- Axelsson, T. (author)
- Linköpings universitet,Njurmedicin,Hälsouniversitetet
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- Müssener, E. (author)
- Linköpings universitet,Njurmedicin,Hälsouniversitetet
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- Grodzinsky, Ewa (author)
- Linköpings universitet,Allmänmedicin,Hälsouniversitetet
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- Midhagen, Gunnar (author)
- Department of Clinical Microbiology and Immunology, University Hospital of Örebro, Sweden
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- Olcén, Per (author)
- Department of Internal Medicine, Hospital of Lidköping
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(creator_code:org_t)
- 2009-07-12
- 2006
- English.
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In: Upsala Journal of Medical Sciences. - : Uppsala Medical Society. - 0300-9734 .- 2000-1967. ; 111:3, s. 339-352
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
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- Background: Antibodies present in coeliac disease may occur in IgA-nephropathy. This raises the question of food intolerance in the disease. Evidence for a true correlation between the two disorders has however been scarce.Design: Sera from 89 patients with IgA-nephropathy and 13 other patients with IgA deposits in the glomeruli of kidney biopsies were analysed for IgA-antibodies to gliadin, endomysium and tissue transglutaminase (92/102 patients).Results: Eleven out of 89 (12.4%) of the patients with IgA-nephropathy and five of the 13 others (38%) had elevated titres of IgA-antibodies to gliadin but, in all cases but one, normal IgA-antibodies to endomysium. Patients with IgA-nephropathy and elevated IgA-antibodies to gliadin had elevated total serum IgA more frequently than patients who had not (p<0.01). Two patients with IgA-nephropathy and one with Hennoch Schönlein's purpura had elevated IgA-antibodies to tissue transglutaminase.Small bowel biopsy in 7 out of 11 IgA-antibodies to gliadin positive patients with IgA-nephropathy was pathologic in three cases (two with Marsh I). One patient with chronic glomerulnephritis also had Marsh I.Conclusions: We found no increased frequency of verified coeliac disease in 89 patients with IgA-nephropathy. Two patients with IgA-nephropathy and one patient with chronic glomerulonephritis with IgA deposits in the kidney biopsy had a Marsh I histopathology. The findings suggest a possible link of celiac disease to IgA-nephropathy and a role for antibodies to food antigens in this disorder.
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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