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Specific immunother...
Specific immunotherapy has long-term preventive effect of seasonal and perennial asthma : 10-year follow-up on the PAT study
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- Jacobsen, L. (author)
- ALK-Abelló, Hørsholm, Denmark
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- Niggemann, B. (author)
- Department of Pediatric Pneumology and Immunology, Charité, Berlin, Germany
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- Dreborg, S. (author)
- Department of Pediatrics, University Hospital of Oslo, Oslo, Norway
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- Ferdousi, Hosne Ara (author)
- Linköpings universitet,Pediatrik,Hälsouniversitetet
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- Halken, S. (author)
- Department of Pediatrics, Hospital of Sønderborg, Sønderborg, Denmark
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- Høst, A. (author)
- Department of Pediatrics, University Hospital of Odense, Odense, Denmark
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- Koivikko, Antti (author)
- Turku Allergy Centre, Turku, Finland
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- Norberg, L.A. (author)
- Department of Pediatrics, University Hospital of Odense, Odense, Denmark
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- Valovirta, E. (author)
- Turku Allergy Centre, Turku, Finland
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- Wahn, U. (author)
- Department of Pediatric Pneumology and Immunology, Charité, Berlin, Germany
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- Möller, C. (author)
- Umeå universitet,Pediatrik,Department of Pediatrics, Umeå University, Umeå, Sweden
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(creator_code:org_t)
- Wiley, 2007
- 2007
- English.
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In: Allergy. European Journal of Allergy and Clinical Immunology. - : Wiley. - 0105-4538 .- 1398-9995. ; 62:8, s. 943-948
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
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- Background: 3-year subcutaneous specific immunotherapy (SIT) in children with seasonal allergic rhinoconjunctivitis reduced the risk of developing asthma during treatment and 2 years after discontinuation of SIT (5-year follow-up) indicating long-term preventive effect of SIT.Objective: We evaluated the long-term clinical effect and the preventive effect of developing asthma 7-years after termination of SIT.Methods: One hundred and forty-seven subjects, aged 16–25 years with grass and/or birch pollen allergy was investigated 10 years after initiation of a 3-year course of SIT with standardized allergen extracts of grass and/or birch or no SIT respectively. Conjunctival provocations were performed outside the season and methacholine bronchial provocations were performed during the season and winter. Asthma was assessed by clinical evaluation.Results: The significant improvements in rhinoconjunctivitis and conjunctival sensitivity persisted at the 10-year follow-up. Significantly less actively treated subjects had developed asthma at 10-year follow-up as evaluated by clinical symptoms [odds ratio 2.5 (1.1–5.9)]. Patients who developed asthma among controls were 24/53 and in the SIT group 16/64. The longitudinal treatment effect when adjusted for bronchial hyper-responsiveness and asthma status at baseline including all observations at 3, 5 and 10 years follow-up (children with or without asthma at baseline, n = 189; 511 observations) was statistically significant (P = 0.0075). The odds ratio for no-asthma was 4.6 95% CI (1.5–13.7) in favor of SIT.Conclusion: A 3-year course of SIT with standardized allergen extracts has shown long-term clinical effects and the potential of preventing development of asthma in children with allergic rhinoconjunctivitis up to 7 years after treatment.Clinical implication: Specific immunotherapy has long-term clinical effects and the potential of preventing development of asthma in children with allergic rhino conjunctivitis up to 7 years after treatment termination.
Keyword
- Asthma
- Long-term effect
- Prevention
- Rhinitis
- Specific immunotherapy
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Jacobsen, L.
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Niggemann, B.
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Dreborg, S.
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Ferdousi, Hosne ...
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Halken, S.
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Høst, A.
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Koivikko, Antti
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Norberg, L.A.
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Valovirta, E.
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Wahn, U.
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Möller, C.
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- Articles in the publication
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Allergy. Europea ...
- By the university
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Linköping University
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Umeå University