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β-Carotene Uptake a...
β-Carotene Uptake and Bioconversion to Retinol Differ Between Human Melanocytes and Keratinocytes
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- Andersson, Eva (author)
- Linköpings universitet,Dermatologi,Hälsouniversitetet
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- Vahlquist, Anders (author)
- Section of Dermatology and Venereology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden
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- Rosdahl, Inger (author)
- Linköpings universitet,Dermatologi,Hälsouniversitetet
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(creator_code:org_t)
- 2001
- 2001
- English.
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In: Nutrition and Cancer. - 0163-5581 .- 1532-7914. ; 39:2, s. 300-306
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- β-Carotene is one of the carotenoids that has been considered to play a role in the natural defense against ultraviolet-induced skin cancer. It is not known whether epidermal cells are able to accumulate β-carotene and, subsequently, convert it to vitamin A. We used normal cultured human keratinocytes and melanocytes to study the uptake, and possible bioconversion to retinol, of authentic or [14C]β-carotene. The uptake was much higher in melanocytes than in keratinocytes, corresponding to a fivefold difference in the intracellular fraction after two days of incubation. An increased level of cellular retinol was noted after one day of β-carotene incubation. The conversion of [C]β-carotene to [14C]retinol peaked at 24 hours of incubation in keratinocytes and melanocytes. The results suggest that β-carotene can function as a local supply of vitamin A in the skin and that melanocytes are especially likely to store β-carotene.
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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