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Search: onr:"swepub:oai:DiVA.org:liu-50011" > Donepezil in Alzhei...

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  • Wallin, Anders,1950Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Wallin, Å.K., Clinical Memory Research Unit, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden, Department of Clinical Sciences, Malmö, Lund University, Malmö University Hospital, SE-205 02 Malmö, Sweden,Institute of Neuroscience, Section of Psychiatry, Göteborg/Sahlgrenska University Hospital, Mölndal, Sweden, Institute of Clinical Neuroscience, Göteborg University, Göteborg, Sweden (author)

Donepezil in Alzheimer's disease : What to expect after 3 years of treatment in a routine clinical setting

  • Article/chapterEnglish2007

Publisher, publication year, extent ...

  • 2006-12-18
  • Basel :S. Karger AG,2007
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:liu-50011
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-50011URI
  • https://doi.org/10.1159/000098052DOI
  • https://gup.ub.gu.se/publication/40191URI
  • https://lup.lub.lu.se/record/165526URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-118228URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-103509URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:12455730URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Background/Aims: Clinical short-term trails have shown positive effects of donepezil treatment in patients with Alzheimer's disease. The outcome of continuous long-term treatment in the routine clinical settings remains to be investigated. Methods: The Swedish Alzheimer Treatment Study (SATS) is a descriptive, prospective, longitudinal, multicentre study. Four hundred and thirty-five outpatients with the clinical diagnosis of Alzheimer's disease, received treatment with donepezil. Patients were assessed with Mini-Mental State Examination (MMSE), Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-cog), global rating (CIBIC) and Instrumental Activities of Daily Living (IADL) at baseline and every 6 months for a total period of 3 years. Results: The mean MMSE change from baseline was positive for more than 6 months and in subgroups of patients for 12 months. After 3 years of treatment the mean change from baseline in MMSE-score was 3.8 points (95% CI, 3.0-4.7) and the ADAS-cog rise was 8.2 points (95% CI, 6.4-10.1). This is better than expected in untreated historical cohorts, and better than the ADAS-cog rise calculated by the Stern equation (15.6 points, 95% CI, 14.5-16.6). After 3 years with 38% of the patients remaining, 30% of the them were unchanged or improved in the global assessment. Conclusion: Three-year donepezil treatment showed a positive global and cognitive outcome in the routine clinical setting. Copyright © 2007 S. Karger AG.

Subject headings and genre

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  • Andreasen, N.Karolinska Institutet,Karolinska Institutet, Department of Neurotec, Karolinska University Hospital, Huddinge, Stockholm, Sweden (author)
  • Eriksson, StureUmeå universitet,Geriatrik,Section of Geriatric Medicine, Department of Community Medicine and Rehabilitation, Umeå University, Umeå, Sweden, Department of Community Medicine and Rehabilitation, Umeå University, Umeå, Sweden(Swepub:umu)ster0022 (author)
  • Batsman, S.Båtsman, S., Department of Primary Care, Kalix Vårdcentral, Kalix, Sweden (author)
  • Nasman, B.Umeå universitet,Geriatrik,Näsman, B., Section of Geriatric Medicine, Department of Community Medicine and Rehabilitation, Umeå University, Umeå, Sweden, Department of Community Medicine and Rehabilitation, Umeå University, Umeå, Sweden (author)
  • Ekdahl, AnneÖstergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Institutionen för nervsystem och rörelseorgan,Geriatriska kliniken(Swepub:liu)annek55 (author)
  • Kilander, LenaUppsala universitet,Geriatrik,Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden(Swepub:uu)lekil226 (author)
  • Grut, M.Department of Geriatric Medicine, Cognitive Section, Danderyd Hospital, Danderyd, Sweden (author)
  • Ryden, M.Rydén, M., Department of Geriatric Medicine, Cognitive Section, Danderyd Hospital, Danderyd, Sweden (author)
  • Wallin, ÅsaLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups(Swepub:lu)med-was (author)
  • Jonsson, Michael,1955Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Institute of Neuroscience, Section of Psychiatry, Göteborg/Sahlgrenska University Hospital, Mölndal, Sweden, Institute of Clinical Neuroscience, Göteborg University, Göteborg, Sweden(Swepub:gu)xjonmi (author)
  • Olofsson, H.Memory Clinic, Uddevalla Hospital, Uddevalla, Sweden (author)
  • Londos, ElisabetLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Clinical Memory Research Unit, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden(Swepub:lu)pski-elo (author)
  • Wattmo, CarinaLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Clinical Memory Research Unit, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden(Swepub:lu)med-cwo (author)
  • Eriksdotter, Jonhagen M.Karolinska Institutet,Eriksdotter Jönhagen, M., Karolinska Institutet, Department of Neurotec, Karolinska University Hospital, Huddinge, Stockholm, Sweden,Department of Geriatric Medicine, Cognitive Section, Danderyd Hospital, Danderyd, Sweden (author)
  • Minthon, LennartLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Clinical Memory Research Unit, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden(Swepub:lu)psyk-lmi (author)
  • Bjorkman, A.Björkman, A., Clinical Memory Research Unit, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden (author)
  • Wunsch, A.Department of Primary Care, Kalix Vårdcentral, Kalix, Sweden (author)
  • Mannberg, L.Department of Community Medicine and Rehabilitation, Umeå University, Umeå, Sweden (author)
  • Kallman, A.Källman, A., Department of Geriatric Medicine, University Hospital Linköping, Linköping, Sweden (author)
  • Hellström, IngridLinköpings universitet,Hälsouniversitetet,Hälsa, Aktivitet, Vård (HAV)(Swepub:liu)inghe59 (author)
  • Soderin, M.Söderin, M., Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden (author)
  • Sjodin, C.Sjödin, C., Karolinska Institutet, Department of Neurotec, Karolinska University Hospital, Huddinge, Stockholm, Sweden (author)
  • Grut, M.Department of Geriatric Medicine, Cognitive Section, Danderyd Hospital, Danderyd, Sweden (author)
  • Mohlin, E.Department of Geriatric Medicine, Cognitive Section, Danderyd Hospital, Danderyd, Sweden (author)
  • Dahl, C.Clinical Memory Research Unit, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden (author)
  • Gustavsson, K.Institute of Clinical Neuroscience, Göteborg University, Göteborg, Sweden (author)
  • Holm, B.Memory Clinic, Uddevalla Hospital, Uddevalla, Sweden (author)
  • Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi (creator_code:org_t)

Related titles

  • In:Dementia and Geriatric Cognitive DisordersBasel : S. Karger AG23:3, s. 150-1601420-80081421-9824

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