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The Discovery of Cellular Immunity in the Atherosclerotic Plaque
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- K Hansson, Goran (author)
- Karolinska Institutet
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- Jonasson, Lena (author)
- Östergötlands Läns Landsting,Linköpings universitet,Kardiologi,Hälsouniversitetet,Kardiologiska kliniken
- (creator_code:org_t)
- 2009
- 2009
- English.
- In: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. - 1079-5642 .- 1524-4636. ; 29:11, s. 1714-1717
- Journal article (peer-reviewed)
Abstract
Subject headings
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- It is now generally accepted that atherosclerosis is an inflammatory/immune disease triggered by LDL accumulation in the artery wall. When discovering T cells and the molecular components of a cellular immune response, we proposed that atherosclerosis is an inflammatory process with an autoimmune component. This notion was met with general skepticism but has gained support from experimental and clinical studies. Here we describe some of the early studies that helped developing this concept.
Keyword
- athersclerosis
- immunity
- inflammation
- cytokines
- T cells
- macrophages
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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