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The effect of trans...
The effect of transvaginal estradiol on bone in aged women; a randomised controlled trial
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- Salminen, Helena (author)
- Karolinska Institutet
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- Sääf, Maria (author)
- Karolinska institutet, Stockholm
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- Johansson, Sven-Erik (author)
- Karolinska Institutet
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- Ringertz, Hans, 1939- (author)
- Karolinska Institutet
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- Strender, Lars-Erik (author)
- Karolinska Institutet
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Saeaef, ME (author)
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(creator_code:org_t)
- Ireland : Elsevier Ireland Ltd, 2007
- 2007
- English.
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In: Maturitas. - Ireland : Elsevier Ireland Ltd. - 0378-5122 .- 1873-4111. ; 57, s. 370-381
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Objectives: To investigate the effect of transvaginal estradiol on bone mineral density and bone metabolism. Methods: One hundred and fifteen women (mean age 73.8 ± 3.2 years) were randomly assigned to a 2-year open-label parallel group clinical trial and were treated with either transvaginal estradiol (7.5 μg/24 h), or no estradiol. Both groups received 400 IU vitamin D and 500 mg calcium/day. The bone mineral density (BMD) was assessed in the hip and spine using DXA technique and in the heel using DXL technique. Results: The intention to treat analysis showed that the increase in BMD in the estradiol group was significant at total hip by 0.6% (P = 0.04) while the control group decreased in their BMD by 0.7%. At lumbar spine the estradiol group increased in BMD by 2.6% (P = 0.011) while the control group increased by 2.2%. Bone turnover markers and PTH-levels decreased while 25-OH vitamin D levels increased in both groups, a probable effect of the calcium and vitamin D supplementation. The bone resorption marker CTx decreased more significantly in the treatment group (P = 0.016). Conclusions: The transvaginal estradiol treatment of 7.5 μg/24 h had a small but significant effect on the BMD of total hip and lumbar spine after a follow-up of 2 years.
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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