FXYD3 Expression in Gliomas and its Clinicopathological Significance

Wang, Ming-Wei (author): Hebei Med Univ, Hosp 1, Dept Neurol, Shijiazhuang, Hebei, Peoples R China

Gu, Ping (author): Hebei Med Univ, Hosp 1, Dept Neurol, Shijiazhuang, Hebei, Peoples R China

Zhang, Zhi-Yong (author): Tangshan Gongren Hosp, Dept Pathol, Tangshan, Hebei, Peoples R China

Zhu, Zhen-Long (author): Hebei Med Univ, Hosp 1, Dept Pathol, Shijiazhuang, Hebei, Peoples R China

Geng, Yuan (author): Hebei Med Univ, Hosp 1, Dept Neurol, Shijiazhuang, Hebei, Peoples R China

Kayed, Hany (author): Univ Heidelberg, Univ Hosp Mannheim, Inst Clin Radiol and Nucl Med, Heidelberg, Germany

Zentgraf, Hanswalter (author): German Canc Res Ctr, D-6900 Heidelberg, Germany

Sun, Xiao-Feng (author): Östergötlands Läns Landsting,Linköpings universitet,Onkologi,Hälsouniversitetet,Onkologiska kliniken US

(creator_code:org_t)

Computers, Materials and Continua (Tech Science Press), 2009
2009
English.
In: Oncology Research. - : Computers, Materials and Continua (Tech Science Press). - 0965-0407 .- 1555-3906. ; 18:4, s. 133-139

Related links:: http://www.cognizant...; show more...; https://urn.kb.se/re...; https://doi.org/10.3...; show less...

Abstract Subject headings

FXYD3, interacting with Na+/K+-ATPase, is considered a cell surface regulator modulating the function of ion pumps and ion channels. The FXYD3 gene was originally cloned from murine mammary tumors and then from human breast tumors. However, no study of FXYD3 has been carried out in gliomas; therefore, we examined FXYD3 expression in gliomas and its clinicopathological significance. FXYD3 expression was immunohistochemically examined in 71 primary gliomas, along with 37 matched adjacent normal brain samples and 8 recurred gliomas. The frequency of strong FXYD3 expression was higher in the primary tumors in either unmatched (p = 0.046) or matched cases (p = 0.02), compared to normal brain tissue. FXYD3 expression was significantly more increased in females than males (p = 0.01), and in multiple site gliomas than single sites (p = 0.02). There was no difference of FXYD3 expression regarding age, tumor location, size, histological type, and tumor grade (p greater than 0.05). The results suggest that FXYD3 expression may be involved in glioma development, especially in multiple gliomas and female patients.

By the author/editor: Wang, Ming-Wei; Gu, Ping; Zhang, Zhi-Yong; Zhu, Zhen-Long; Geng, Yuan; Kayed, Hany; show more...; Zentgraf, Hanswa ...; Sun, Xiao-Feng; show less...

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