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Colorimetric sensing: Small 21/2009
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- Aili, Daniel (author)
- Linköpings universitet,Sensorvetenskap och Molekylfysik,Tekniska högskolan
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- Selegård, Robert (author)
- Linköpings universitet,Molekylär fysik,Tekniska fakulteten
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- Baltzer, Lars (author)
- Uppsala University
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- (creator_code:org_t)
- John Wiley & Sons, 2009
- 2009
- English.
- In: Small. - : John Wiley & Sons. - 1613-6810 .- 1613-6829. ; 5:21
- Journal article (other academic/artistic)
Abstract
Subject headings
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- The cover picture illustrates a novel concept for colorimetric protein sensing based on the controllable assembly of polypeptide-functionalized gold nanoparticles. Recognition of the analyte is accomplished by polypeptide-based synthetic receptors immobilized on gold nanoparticles. Also present on the particle surface is a de novo-designed helix-loop-helix polypeptide that homodimerizes and folds into four-helix bundles in the presence of Zn2+, resulting in particle aggregation. Analyte binding interferes with the folding-induced aggregation, giving rise to a clearly detectable colorimetric response.
Keyword
- NATURAL SCIENCES
- NATURVETENSKAP
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- vet (subject category)
- art (subject category)
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- Aili, Daniel
- Selegård, Robert
- Baltzer, Lars
- Enander, Karin
- Liedberg, Bo
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- Linköping University
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