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Changes of gap junc...
Changes of gap junctional cell-cell communication in overactive detrusor in rats
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- Li, Longkun (author)
- Center of Urology, Southwest Hospital, Third Military Medical University, Chongqing, China
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- Jiang, Chonghe (author)
- Linköpings universitet,Institutionen för biomedicin och kirurgi,Hälsouniversitetet,Sivert Lindström
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- Hao, Ping (author)
- 3Center of Oncology, Xinqiao Hospital, Third Military Medical University, Chongqing, China
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- Li, Weibing (author)
- Center of Urology, Southwest Hospital, Third Military Medical University, Chongqing, China
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- Song, Caiping (author)
- Center of Urology, Southwest Hospital, Third Military Medical University, Chongqing, China
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- Song, Bo (author)
- Center of Urology, Southwest Hospital, Third Military Medical University, Chongqing, China
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(creator_code:org_t)
- American Physiological Society, 2007
- 2007
- English.
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In: American Journal of Physiology - Cell Physiology. - : American Physiological Society. - 0363-6143 .- 1522-1563. ; 293:5, s. c1627-1635
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- To evaluate the changes in intercellular communication through gap junctions in detrusor overactivity (DO), we studied 23 adult female Wistar rats with DO after partial outflow obstruction (DO group) and 13 sham-operated rats (control group). The two groups were compared by means of urodynamics, light and electron microscopy, expression of Cx40, Cx43, and Cx45 mRNA genes with RT-PCR, Cx43 protein with Western blot analysis, and functional intercellular communication with scrape loading dye transfer (SLDT) and fluorescence recovery after photobleaching (FRAP). The number of gap junctions and the expression of connexin mRNA and Cx43 protein were increased in DO rats, and intercellular communication through gap junctions increased after 6 wk of partial outflow obstruction as assessed with SLDT and FRAP techniques. The findings provide a theoretical rationale for using Cx43 antagonists and gap junction inhibitors in the treatment of patients with overactive detrusor secondary to partial bladder outflow obstruction.
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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