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Birthweight and the...
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Cardwell, C RQueens University Belfast
(författare)
Birthweight and the risk of childhood-onset type 1 diabetes: a meta-analysis of observational studies using individual patient data
- Artikel/kapitelEngelska2010
Förlag, utgivningsår, omfång ...
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2010-01-10
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Springer Science and Business Media LLC,2010
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:liu-54507
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-54507URI
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https://doi.org/10.1007/s00125-009-1648-5DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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We investigated whether children who are heavier at birth have an increased risk of type 1 diabetes. Relevant studies published before February 2009 were identified from literature searches using MEDLINE, Web of Science and EMBASE. Authors of all studies containing relevant data were contacted and asked to provide individual patient data or conduct pre-specified analyses. Risk estimates of type 1 diabetes by category of birthweight were calculated for each study, before and after adjustment for potential confounders. Meta-analysis techniques were then used to derive combined ORs and investigate heterogeneity between studies. Data were available for 29 predominantly European studies (five cohort, 24 case-control studies), including 12,807 cases of type 1 diabetes. Overall, studies consistently demonstrated that children with birthweight from 3.5 to 4 kg had an increased risk of diabetes of 6% (OR 1.06 [95% CI 1.01-1.11]; p = 0.02) and children with birthweight over 4 kg had an increased risk of 10% (OR 1.10 [95% CI 1.04-1.19]; p = 0.003), compared with children weighing 3.0 to 3.5 kg at birth. This corresponded to a linear increase in diabetes risk of 3% per 500 g increase in birthweight (OR 1.03 [95% CI 1.00-1.06]; p = 0.03). Adjustments for potential confounders such as gestational age, maternal age, birth order, Caesarean section, breastfeeding and maternal diabetes had little effect on these findings. Children who are heavier at birth have a significant and consistent, but relatively small increase in risk of type 1 diabetes.
Ämnesord och genrebeteckningar
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Birthweight
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Epidemiology
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Meta-analysis
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Risk factors
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Type 1 diabetes mellitus
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MEDICINE
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MEDICIN
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Stene, L CNorwegian Institute Public Health
(författare)
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Joner, GOslo University Hospital
(författare)
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Davis, E AUniversity Western Australia
(författare)
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Cinek, OCharles University Prague
(författare)
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Rosenbauer, JUniversity Dusseldorf
(författare)
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Ludvigsson, JohnnyÖstergötlands Läns Landsting,Linköpings universitet,Pediatrik,Hälsouniversitetet,Barn- och ungdomskliniken i Linköping(Swepub:liu)johlu29
(författare)
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Castell, CAdvisory Comm Diabet Catalonia, Barcelona, Spain
(författare)
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Svensson, JGlostrup University Hospital
(författare)
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Goldacre, M JUniversity of Oxford
(författare)
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Waldhoer, TMedical University of Vienna
(författare)
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Polanska, JSilesian Technical University
(författare)
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Gimeno, S G AUniversity Fed Sao Paulo
(författare)
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Chuang, L-MNational Taiwan University Hospital
(författare)
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Parslow, R CUniversity of Leeds
(författare)
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Wadsworth, E J KCardiff University
(författare)
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Chetwynd, AUniversity Lancaster
(författare)
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Pozzilli, PUniversity Campus Biomed, Rome, Italy
(författare)
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Brigis, GRiga Stradins University
(författare)
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Urbonaite, BKaunas University of Medicine
(författare)
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Sipetic, SUniversity of Belgrade
(författare)
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Schober, EMedical University of Vienna
(författare)
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Ionescu-Tirgoviste, CN Paulescu Institute Diabet, Nutr and Metab Disease Clin, Bucharest, Romania
(författare)
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de Beaufort, C EPediat Clin, Luxembourg
(författare)
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Stoyanov, DChildrens Diabet Centre, Sofia, Bulgaria
(författare)
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Buschard, KRigshosp, Copenhagen
(författare)
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Patterson, C CQueens University Belfast
(författare)
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Queens University BelfastNorwegian Institute Public Health
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:DIABETOLOGIA: Springer Science and Business Media LLC53:4, s. 641-6510012-186X1432-0428
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Till lärosätets databas
- Av författaren/redakt...
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Cardwell, C R
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Stene, L C
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Joner, G
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Davis, E A
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Cinek, O
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Rosenbauer, J
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visa fler...
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Ludvigsson, John ...
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Castell, C
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Svensson, J
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Goldacre, M J
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Waldhoer, T
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Polanska, J
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Gimeno, S G A
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Chuang, L-M
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Parslow, R C
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Wadsworth, E J K
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Chetwynd, A
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Pozzilli, P
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Brigis, G
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Urbonaite, B
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Sipetic, S
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Schober, E
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Ionescu-Tirgovis ...
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de Beaufort, C E
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Stoyanov, D
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Buschard, K
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Patterson, C C
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visa färre...
- Artiklar i publikationen
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DIABETOLOGIA
- Av lärosätet
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Linköpings universitet